某些新的N-苯乙烯基脲及N-苄基硫脲衍生物的合成  

SYNTHESIS OF SOME NEW N-STYRYL UREA AND N-BENZYL THIOUREA DERIVATIVES

作　　者：陈茹玉[1] 杨华铮[1] 汪复 Chen Ruyu;Yang Huazheng;Wang Fu(Institute of Elemento-Organic Chemistry,Nankai University,Tianjiri)

机构地区：[1]南开大学元素有机化学研究所

出　　处：《高等学校化学学报》1983年第2期207-212,共6页Chemical Journal of Chinese Universities

摘　　要：用苯乙烯基异氰酸脂与脂肪胺反应合成了6个新的N-苯乙烯基脲化合物,产品收率多在90%以上。通过α-甲基苄基和对氯α-甲基苄基异硫氰酸脂与脂肪胺反应制备了12个新的N-苄基衍生物。产品收率多在80%以上。初步探讨了“一步法”,即苄胺或取代苄胺与脂肪胺。二硫化碳直接作用合成相应的N-苄基硫脲衍生物的可能性。对所合成的新化合物进行了初步生测,结果表明它们都有不同程度的除草活性。其中有几个化合物除草活性高于除草剂1号■。Six new substituted compounds of urea of the general formula ■ have beenprepared by the reactions of a styrylisocyanate with appropriate alkyl-amines.The yields of these compounds are mostly over ninety percent.By the reactions ofα-methylbenzyl or p-chloro-α-methylbenzyl isothio-cyanates with different alkylamines,twelve new substituted thioureas havebeen synthesized.Their general formula is ■.The yields of most of the products are over eighty percent.An attempt has been made to synthesize the above substituted thioureas by means of One Step Method,namely,the direct reaction of substituted benzylamine,alkylamine and carbon disulfide.The result shows that whereas dimethylamine can react successfully with the benzyl-or substituted benzylamine and carbon disulfide to give the corresponding substituted thioureas with yields of about seventy percent.Methylamine did not react normally,and the products are mainly sym-dibenzyl or sym-di-substituted benzyl thioureas.Bioassay for these compounds shows that they have herbicidal activi-ties,some of which rank higher than HERBICIDE No.1 ■。

关 键 词：苯乙烯基 硫脲衍生物 脂肪胺 除草活性 异硫氰酸 二硫化碳 苄胺 异氰酸脂 

分 类 号：O62[理学—有机化学]