LSD1在胚胎干细胞分化中的作用  

Role of LSD1 in Differentiation of Embryonic Stem Cells

作　　者：刘海港 孙立栋 宋檀婧 Liu Haigang;Sun Lidong;Song Tanjing(Department of Biochemistry and Molecular Biology,Basic Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学基础医学院生物化学与分子生物学系,武汉430030

出　　处：《华中科技大学学报（医学版）》2021年第5期669-673,共5页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金面上项目(No.31971149,No.31871284);国家自然科学基金青年基金项目(No.31800641)。

摘　　要：组蛋白赖氨酸去甲基化酶1A[lysine(K)-specificdemethylase1A,KDM1A或LSD1]能脱去组蛋白H3上的第4位赖氨酸残基(H3K4)和第9位赖氨酸残基(H3K9)的单甲基化和二甲基化修饰,在基因的表观遗传调控、胚胎发育以及肿瘤的发生发展中都发挥着重要的作用。虽然截止目前关于LSD1在胚胎干细胞分化中的作用已有多篇文献述及,但缺乏系统地总结和整理。该文就LSD1在胚胎干细胞分化中的作用进行综述。Lysine-specific demethylase 1 A(LSD1,also called KDM1 A)can remove the methyl group from the mono-and dimethylated lysine 4 and lysine 9 in histone H3(H3 K4 and H3 K9),thus playing a significant role in epigenetic regulation of gene,embryonic development and tumorigenesis.Although,up to now,many studies about the role of LSD1 in differentiation of embryonic stem cells have been reported,there is no systematic summary and analysis.This paper is a review about the role of LSD1 in differentiation of embryonic stem cells.

关 键 词：组蛋白赖氨酸去甲基化酶1 胚胎干细胞 分化 

分 类 号：R34[医药卫生—基础医学]