一氰乙基化β-二酮的合成及其异构化(Ⅱ)  

MONOCYANOETHYL-β-DIKETONES AND THEIR ISCMERIZATION(Ⅱ)

作　　者：黄化民[1] 李葆[2] 战永复[2] 沙德有 Huang Huamin;Li Bao;Zhan Yongfu;Sha Deyou(Department of chemistry,Jilin University,changchun;Department of chemistry,Jilin Teacher's College,Jilin)

机构地区：[1]吉林大学化学系 [2]吉林师范学院化学系

出　　处：《高等学校化学学报》1984年第1期133-135,共3页Chemical Journal of Chinese Universities

摘　　要：前文已报道,β-二酮类与丙烯腈反应,我们分离出来了一氰乙基化合物,进而异构化为5,6-二取代3,4-二氢化-2(1H)吡啶酮。本文又合成了三个新的一氰乙基化合物:4-乙酰基-5-氧代辛腈(Ⅰ),4-乙酰基-6-甲基-5-氧代庚腈(Ⅱ),4-乙酰基-7-甲基-5-氧代辛腈(Ⅲ)。β-Diketones(butyrylacetone,isobutyrylacetone,isovalerylacetone)were treated with acrylonitrile in the presence of aqueous potassium hydroxide giving monocyanoethylated-β-diketones(Ⅰ)-(Ⅲ),which by heating with HCl were isomerized to the corresponding 3,4-dihydro-2-(1H)pyridones(Ⅳ)-(Ⅵ).(Ⅰ)-(Ⅲ)were hydrolyzed to the ketoacids(Ⅶ)-(Ⅸ).semicarbazone(Ⅹ)-(ⅩⅤ)were prepared from 5-acetyl-6-methyl-3,4dihydyo-2(1H)pyridones;pyrazole(ⅩⅥ)-(ⅩⅨ)were prepared fromβ-diketoncids.compounds(Ⅰ)-(ⅩⅪ)were reported for the first time.

关 键 词：氰乙基化 (Ⅱ) (Ⅲ) 异构化 吡啶酮 丙烯腈 合成 

分 类 号：O62[理学—有机化学]