芳香烃受体激动药药物不良反应信号的挖掘与评价  

Excavation and evaluation of the adverse reaction signals induced by aryl hydrocarbon receptor agonists

作　　者：汪静 郑淑芬 钟诗龙 WANG Jing;ZHENG Shu-fen;ZHONG Shi-long(School of Biology and Biological Engineering,South China University of Technology,Guangzhou 510006,Guangdong Province,China;Department of Pharmacy,Guangdong Academy of Medical Sciences,Giuingdong Cardiovascular Institute,Guangzhou 510080,Guangdong Province,China;Department of Medical Research,Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Giuingdong Cardiovascular Institute,Guangzhou 510080,Guangdong Province,China)

机构地区：[1]华南理工大学生物科学与工程学院,广东广州510006 [2]广东省人民医院、广东省医学科学院药学部,广东广州510080 [3]广东省人民医院、广东省医学科学院医学研究部/广东省冠心病防治研究重点实验室,广东广州510080

出　　处：《中国临床药理学杂志》2021年第19期2704-2708,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金面上基金资助项目(81872934,81673514);广东省重点领域研发计划“精准医学与干细胞”重大科技专项基金资助项目(2019B020229003)。

摘　　要：目的挖掘和评价芳香烃受体(AHR)激动药的药物不良反应(ADR)信号,探讨AHR激活而导致ADR发生的潜在机制。方法用比例报告比值比和报告比值比法对美国食药监局不良事件报告系统内AHR激动药的ADR信号进行检测,并对纳入研究的信号进行整合分析与评价。结果数据经提取和清洗后纳入以AHR激动药(包括卡比多巴、多巴胺、雷洛昔芬、舒林酸、氟他胺、来氟米特、地奥司明以及咪喹莫特)为怀疑药物的报告共85 353份,挖掘得到2 787个ADR信号。ADR信号涉及到27个系统器官分类,主要集中于胃肠道系统、全身性疾病及给药部位损伤、各项检查指标异常、神经系统、心血管系统及骨骼肌肉损伤等方面。结论 AHR激动药可引起多个系统的损伤。应重点关注胃肠道反应、心脑血管毒性、肌肉骨骼病变、肝肾损伤及临床生化指标异常等,并加强用药部位病变的监测,降低临床用药的风险。Objective To excavate and evaluate the adverse drug reactions(ADR) signals of aryl hydrocarbon receptor(AHR) agonists,and discuss the potential mechanism of adverse reactions caused by AHR activation.Methods The methods of proportional reporting ratio(PRR) and reporting odds ratio(ROR) were used to detect the adverse reaction signals of AHR agonists in the adverse event reporting system of the Food and Drug Administration.And the signals included in this research were integrately analyzed and evaluated.Results After extracting and cleaning,a total of 85 353 reports of AHR agonists(including carbidopa,dopamine,raloxifene,sulindac,flutamide,leflunomide,diosmin,and imiquimod) were included,and 2 787 ADRs signals were mined.The ADR signals involved 27 system organ classifications,which mainly focused on the gastrointestinal system,systemic diseases and medication site damage,abnormal examination indicators,nervous system,cardiovascular system,and skeletal muscle damage.Conclusion AHR agonists can cause damage to multiple systems.Attention should be paid to gastrointestinal reactions,cardiocerebrovascular toxicity,musculoskeletal lesions,liver and kidney injure,and abnormal clinical biochemical indicators,and the monitoring of the lesions of the medication site should be strengthened to reduce the risk of clinical medication.

关 键 词：芳香烃受体激动药 药物不良反应 信号 数据挖掘 

分 类 号：R97[医药卫生—药品]