生物样本中抗精神病药物分离与检测方法的趋势与进展  

Trends and advances in the separation and detection methods of antipsychotics in biological matrices

作　　者：范理菊 崔艳军 安静[2] 董占军[1,2] FAN Liju;CUI Yanjun;AN Jing;DONG Zhanjun(College of Graduate Studies,Hebei Medical University,Shijiazhuang 050017;Pharmaceutical Department,Hebei General Hospital,Shijiazhuang 050051)

机构地区：[1]河北医科大学研究生学院,石家庄050017 [2]河北省人民医院药学部,石家庄050051

出　　处：《分析试验室》2021年第10期1234-1240,共7页Chinese Journal of Analysis Laboratory

摘　　要：抗精神病药主要用于治疗精神分裂症及其他精神性疾病,这类药物有效浓度低、遗传变异度大、药物的依从性低。临床通过对该类药物进行治疗药物监测从而实现患者用药方案个体化。在法医学中,生物样本中抗精神病药物的检测对解释和确定死亡原因也至关重要。因此,开发高灵敏、高选择性的生物分析方法至关重要。本文汇总了近5年来抗精神病药物检测的研究方法,重点阐述精神类药物分析在样品制备、生物基质分析中的研究进展。Antipsychotics are widely used to treat schizophrenia and other psychotic symptoms,but these drugs have low effective concentration,large geneticvariation,and low drug compliance. The rapeutic drug monitoring is a tool to optimize the therapeutic regimens in clinical practice. In forensic settings, the detection of antipsychotic drugs in biological samples is also crucial for explaining and determining the cause of death.Therefore,it is very important to develop highly sensitive and selective biological analysis methods. We summarized the detection methods of antipsychotic drug in the past five years,and focused on the advance of analysis technology for antipsychotics in sample pretreatment,biological matrix.

关 键 词：抗精神病药 样品前处理 分析技术 生物基质 

分 类 号：O65[理学—分析化学]