A Green Approach to Producing Polymer Microparticles for Local Sustained Release of Flavopiridol  

作　　者：Matthew J.OWEN Jasper H.N.YIK Congwang YE Brianca NETTO Dominik R.HAUDENSCHILD Gang-yu LIU 

机构地区：[1]Department of Chemistry,University of California,One Shields Avenue,Davis,California,95616,USA [2]Department of Orthopedic Surgery,University of California-Davis School of Medicine,4635 Second Ave.,Sacramento,California,95817,USA [3]Materials Engineering Division,Lawrence Livermore National Laboratory,Livermore,California,94550,USA

出　　处：《Chemical Research in Chinese Universities》2021年第5期1116-1124,共9页高等学校化学研究（英文版）

基　　金：This work was supported by the DOD(CDMRP Award PR171305)and UC Davis.

摘　　要：Poly(lactic-co-glycolic acid)(PLGA)microparticles represent an important class of materials used for drug delivery.Current synthesis frequently uses conventional emulsion,where dichloromethane(DCM)is used as the organic phase solvent.Due to the health and environmental toxicity of DCM and its slow degradation,this work replaces DCM with a greener solvent,dimethyl carbonate(DMC).

关 键 词：RELEASE replace EMULSION 

分 类 号：O62[理学—有机化学]