Comparative research between acupuncture and Climen in treatment of menopausal hot flashes:A randomized controlled trial  

针灸与克龄蒙治疗更年期潮热比较研究

作　　者：Hai-tao TU Xin ZHOU Xun ZHUANG Jun HE Zhong-hao XIONG 涂海涛;周鑫;庄珣;贺君;熊中豪(广州中医药大学第一附属医院肾病科,中国广州510405;重庆市中医院内分泌科,中国重庆400021;广州中医药大学第一附属医院康复中心,中国广州510405;重庆市中医院针灸科,中国重庆400021)

机构地区：[1]Department of Nephrology,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China [2]Department of Endocrinology,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400021,China [3]Department of Rehabilitation Center,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China [4]Department of Acupuncture-moxibustion,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 4000211,China

出　　处：《World Journal of Acupuncture-Moxibustion》2021年第4期285-290,共6页世界针灸杂志（英文版）

基　　金：Supported by Guangdong Education Department Youth Innovation Talent Project(Natural Science):2018 KQNCX043;Chongqing Science&Health Jointed Project of Technology Innovation and Application Development of Traditional Chinese Medicine:2020 ZY3600;Zhang Xijian’s National Famous Chinese Medicine Physician Studio of State Administration of Traditional Chinese Medicine;Surface Project of Guangdong Provincial Administration of Traditional Chinese Medicine:20191114。

摘　　要：Objective:To compare the therapeutic effect on menopausal hot flashes between acupuncture and Climen so as to provide a new approach to the treatment of this disease.Methods:A total of 80 cases in line with inclusion criteria were randomized into a treatment group(treated with acupuncture) and a control group(oral administration with climen),40 cases in each one.The treatment for 1 month was as 1 course and lasted consecutively for 2 courses.Before and after treatment,the contents of serum estrogen(estradiol,E_(2)) and 5-hydroxytryptamine(HT) and the scores of the attack frequency and severity scale of hot flashes and sweating,domestic modified Kupperman scale and traditional Chinese medicine(TCM) symptom scale were observed,and the clinical therapeutic effect was evaluated in the two groups separately.Results:Before treatment,there was no difference in the content of E_(2) and 5-HT,the score of hot flashes and sweating,Kupperman score and TCM symptom score in the patients between two groups,indicating the comparability(all P>0.05).Compared with the data before treatment,the contents of serum E_(2)(treatment group vs control group:22.24±11.02 vs 33.12±1.01;22.11±10.19 vs 25.29±2.23) and5-HT(treatment group vs control group:96.12±8.21 vs 131.21±30.21;96.98±7.99 vs 108.29±22.08),the score of hot flashes and sweating(treatment group vs control group:8.24±1.02 vs 3.12±1.01;8.11±1.19 vs 5.29±2.23),Kupperman score(treatment group vs control group:26.12±2.21 vs11.21±0.21;26.98±1.99 vs 18.29±2.08) and TCM symptom score(treatment group vs control group:18.97±3.87 vs 10.12±0.16;19.01±2.29 vs 15.61±2.89) were statistically different after treatment in the two groups(all P<0.05).After treatment,the contents of serum E_(2) and 5-HT,the score of hot flashes and sweating,Kupperman score and TCM symptom score in the treatment group were all different statistically compared with the control group(all P<0.05).There was statistical difference in clinical therapeutic effect in the patients between two group,in whObjective:To compare the therapeutic effect on menopausal hot flashes between acupuncture and Climen so as to provide a new approach to the treatment of this disease.Methods:A total of 80 cases in line with inclusion criteria were randomized into a treatment group(treated with acupuncture) and a control group(oral administration with climen),40 cases in each one.The treatment for 1 month was as 1 course and lasted consecutively for 2 courses.Before and after treatment,the contents of serum estrogen(estradiol,E_(2)) and 5-hydroxytryptamine(HT) and the scores of the attack frequency and severity scale of hot flashes and sweating,domestic modified Kupperman scale and traditional Chinese medicine(TCM) symptom scale were observed,and the clinical therapeutic effect was evaluated in the two groups separately.Results:Before treatment,there was no difference in the content of E_(2) and 5-HT,the score of hot flashes and sweating,Kupperman score and TCM symptom score in the patients between two groups,indicating the comparability(all P>0.05).Compared with the data before treatment,the contents of serum E_(2)(treatment group vs control group:22.24±11.02 vs 33.12±1.01;22.11±10.19 vs 25.29±2.23) and5-HT(treatment group vs control group:96.12±8.21 vs 131.21±30.21;96.98±7.99 vs 108.29±22.08),the score of hot flashes and sweating(treatment group vs control group:8.24±1.02 vs 3.12±1.01;8.11±1.19 vs 5.29±2.23),Kupperman score(treatment group vs control group:26.12±2.21 vs11.21±0.21;26.98±1.99 vs 18.29±2.08) and TCM symptom score(treatment group vs control group:18.97±3.87 vs 10.12±0.16;19.01±2.29 vs 15.61±2.89) were statistically different after treatment in the two groups(all P<0.05).After treatment,the contents of serum E_(2) and 5-HT,the score of hot flashes and sweating,Kupperman score and TCM symptom score in the treatment group were all different statistically compared with the control group(all P<0.05).There was statistical difference in clinical therapeutic effect in the patients between two group,in wh

关 键 词：Menopausal hot flashes Kidney yin deficiency ACUPUNCTURE CLIMEN Randomized controlled trial(RCT) 

分 类 号：R246.3[医药卫生—针灸推拿学]