Bifunctional Fluoroalcohol Catalysts Enabled Sustainable Synthesis of Poly(amino acid)s  

作　　者：Wenjing He Youhua Tao 

机构地区：[1]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Renmin Street 5625,Changchun,Jilin 130022,China [2]University of Science and Technology of China,Hefei,Anhui 230026,China

出　　处：《Chinese Journal of Chemistry》2021年第8期2119-2124,共6页中国化学（英文版）

基　　金：Research reported in this publication was supported by the National Natural Science Foundation of China(Nos.91856113,51873211).

摘　　要：A series of novel bifunctional single-molecule hydrogen-bonding organocatalysts based on fluorinated tertiary alcohol were synthe-sized to mediate the metal-free polymerization of α-amino acid N-carboxyanhydride(NCA)monomer.Through the screening of catalysts,the polymerizati on catalyzed by the preferred bifun ctional fluoroalcohol catalyst proceeded in a fast and con trolled manner,af-fording high molecular weight polypeptide up to 35.2 ×10^(4) Da with relatively narrow molecular weight distribution(D<1.20).A phenomenon of self-accelerating effect of polymerization induced by a-helical structure of polypeptides was observed,and a possible polymerization pathway has been discussed.

关 键 词：BIFUNCTIONAL ORGANOCATALYST FLUOROALCOHOL Amino acid POLYMERIZATION 

分 类 号：O64[理学—物理化学]