Commiphoroids G_(1)-G_(3), H and I, Five Terpenoid Dimers as Extracellular Matrix Inhibitors from Resina Commiphora  

作　　者：Lu Dong Jian-Bing Jiang Yong-Ming Yan Shu-Mei Wang Yong-Xian Cheng 

机构地区：[1]School of Pharmaceutical Sciences,Shenzhen University Health Science Center,Shenzhen,Guangdong 518060,China [2]Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China

出　　处：《Chinese Journal of Chemistry》2021年第8期2172-2180,共9页中国化学（英文版）

基　　金：This study was supported financially by the National Science Fund for Distinguished Young Scholars(No.81525026);the National Key R&D Program of China(No.2017YFA0503900);the She nzhe n Fundame ntal Research Program(No.JCYJ20200109114003921);the SZU Top Ranking Project(No.86000000210);the Natural Science Research Project of Shenzhen University(2019122);the SZU Medical Young Scientist Program.

摘　　要：Commiphoroids G_(1)-G_(3),H and I(1-5),five new terpenoid dimers were isolated from Resina Commiphora.Their structures and absolute configurations were determined by using spectroscopic,computational and crystallographic methods.Biological evaluation of these terpenoid dimers against renal fibrosis reveals that 5 inhibits extracellular matrix components including fibronectin and colla-gen I in a concentration-dependent manner.

关 键 词：Resina Commiphora Natural products Terpenoid dimers Structural elucidation Anti-renal fibrosis 

分 类 号：O63[理学—高分子化学]