Harpagide Inhibits Microglial Activation and Protects Dopaminergic Neurons as Revealed by Nanoelectrode Amperometry  

作　　者：Fu-Li Zhang Yun Tang Hong Jiang Xiao-Ke Yang Wei-Hua Huang 

机构地区：[1]College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei 430072,China

出　　处：《Chinese Journal of Chemistry》2021年第8期2188-2194,共7页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.21725504,22090050,22090051 and 21721005).

摘　　要：Parkinson's disease(PD)is one of the most comm on n euroge nerative diseases(NDDs),characterized as less n eurotra nsmitter release and loss of dopaminergic(DAergic)neurons with microglial inflammatory response as a key player.Natural product harpagide with anti-inflammatory function is a potential therapeutic drug of PD,but its role towards microglial activation and inflammation-mediated neuronal injury remained unsure.

关 键 词：Nanotechnology Reactive oxygen species Vesicles HARPAGIDE NEUROCHEMISTRY 

分 类 号：TB383[一般工业技术—材料科学与工程]