Design, Synthesis and Biological Evaluation of Novel α-Acyloxycarboxamide-Based Derivatives as c-Met Inhibitors  

作　　者：Yu-juan Feng Yu-Lin Ren Li-Ming Zhao Guo-Qiang Xue Wen-Hao Yu Jia-Qi Yang Jun-Wei Liu 

机构地区：[1]Northwest Minzu University,Lanzhou,Gansu 730030,China [2]Department of Public Health,The Second Provincial People's Hospital of Gansu,Lanzhou,Gansu 730030,China

出　　处：《Chinese Journal of Chemistry》2021年第8期2241-2250,共10页中国化学（英文版）

基　　金：This work was supported by the Fundamental Research Funds for the Central Universities(Nos.31920170193 and 31920200026).

摘　　要：Dysregulated HGF/c-Met signalling has been associated with many human cancers,poor clinical outcomes,and even resistance acquisition to some approved targeted therapies.As such,c-Met kinase has emerged as an attractive target for anticancer drug discovery.

关 键 词：4-(2-Fluorophenoxy)quinoline derivatives c-Met inhibitors Passerini reaction a-Acyloxycarboxamide Biological evaluation 

分 类 号：TQ460.1[化学工程—制药化工]