经钛杂环合成立体选择的三取代乙烯  

Stereoselective Synthesis of Trisubstituted Alkenes via Titanocycles

作　　者：刘以寅[1] 陈美文[1] 李岩 王积涛[2] Liu Yiyin;Chen Meiwen;Li Yaa;Wang Jitao(Institute of Elomento-Organic Chemistry,Nankai University,Tianjin;Department of Chemistry,Nankai University,Tianjin)

机构地区：[1]南开大学元素有机化学研究所 [2]南开大学化学系

出　　处：《高等学校化学学报》1985年第12期1083-1088,共6页Chemical Journal of Chinese Universities

摘　　要：用连续法改进了Masai-Rausch合成钛杂环及烯烃的反应,提高了烯烃收率及Cp_(2)TiCl_(2)回收率,以不对称炔烃为底物合成了十二组烯烃,其中两组为单一构型的烯,其余为异构体混合物,除常规分析外,还分离分析了钛杂环中间物、分析核磁谱等,确定了烯烃的结构及异构体相对量。By previously reported modified Masai-Rausch method for synthesizing titano-Cycles, followed by add hydrolysis, trisubstituted alkenes were synthesized, yields obtained were higher than that reported in literature.Starting from unsymmetrical alkyne substrates, twelve different types of substituted alkenes were synthesized, among which only two were found of single component, others were of isomer mixtures.Besides conventional analytical methods, NMR spectral analysis of titanocycle intermedlates and the products was used to identify the isomeric structures as well as their relative contents.

关 键 词：立体选择 异构体 常规分析 杂环合成 炔烃 分离分析 中间物 

分 类 号：O62[理学—有机化学]