草酸单乙酯三尖杉碱酯的合成及其在三尖杉酯类生物碱合成中的应用  

The Synthesis of Ethyl Cephalotaxinyl Oxalate and Its Application in the Synthesis of Cephalotaxus Ester Alkaloids

作　　者：刘兴平[1] 王永铿 李绍白[1] 潘鑫复[1] 李裕林[1] 黄文魁 Liu Xingping;Wang Yongkeng;Li Shaobai;Pan Xinfu;Li Yulin;Huang Wenkui(Institute of Organic Chemistry,Lanzhou University,Lanzhou)

机构地区：[1]兰州大学有机化学研究所 [2]福建省中医研究所

出　　处：《高等学校化学学报》1988年第9期912-914,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金。

摘　　要：用醇钠催化的酯交换方法合成了草酸单乙酯三尖杉碱酯(4),并用4和格氏试剂反应,得到合成三尖杉酯类生物碱的关键中间体α-酮酰基三尖杉碱(2),简化了已报道的一些三尖杉酯类生物碱的合成方法。In this wrok, ethyl cephalotaxinyl oxalate was prepared by ester exchange and the synthesis of the key intermediate, α-keto-acetyl-cephalotaxine, was achieved by treating this oxalate with a Grignard reagent. This constitutes an efficient modification of previously reported mathods for the synthesis of cephalotaxus este ralkaloids.

关 键 词：草酸单乙酯三尖杉碱酯 α-酮酰 三尖杉碱 

分 类 号：R28[医药卫生—中药学]