GnRH-α和孕三烯酮在子宫内膜异位症患者腹腔镜术后辅助治疗中的应用效果比较  

Comparison of effect of GnRH-α versus gestrinone in adjuvant treatment of endometriosis after laparoscopic surgery

作　　者：刘守燕[1] 朱景瑞[1] 李培培 Liu Shouyan;Zhu Jingrui;Li Peipei(Department of Obstetrics and Gynecology,Pingdingshan First People’s Hospital,Pingdingshan 467000,China)

机构地区：[1]河南省平顶山市第一人民医院妇产科,467000

出　　处：《中国实用医刊》2021年第15期101-104,共4页Chinese Journal of Practical Medicine

摘　　要：目的对比观察促性腺激素释放激素激动剂(GnRH-α)和孕三烯酮在子宫内膜异位症(EMS)患者腹腔镜术后辅助治疗中的应用效果。方法抽取2019年1月至2020年6月于平顶山市第一人民医院就诊的116例EMS患者,按照随机数字表法分为对照组和观察组,每组58例。对照组采用孕三烯酮进行术后辅助治疗,观察组采用GnRH-α进行术后辅助治疗。比较两组患者治疗前及治疗6个月后性激素水平[雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)]、生存质量[子宫内膜异位症生存质量量表(EHP-5)评分]变化,比较治疗6个月期间两组围绝经期症状发生情况、药物不良反应发生情况及复发情况。结果治疗6个月后,两组E2、LH、FSH、EHP-5评分均较治疗前降低,且观察组低于对照组(P<0.05)。治疗6个月期间,两组各项围绝经期症状发生率、药物不良反应发生率比较差异未见统计学意义(P>0.05);观察组复发率(0.00%,0/58)低于对照组(6.89%,4/58),P<0.05。结论相较于孕三烯酮,GnRH-α在EMS患者腹腔镜术后辅助治疗中可取得更显著疗效,有助于调节其性激素水平,减少术后复发,有效改善患者的生存质量,且可确保用药安全性。Objective To compare the effect of gonadotropin releasing hormone agonist(GnRH-α)and gestrinone in the adjuvant treatment of endometriosis(EMS)after laparoscopic surgery.Methods A total of 116 patients with EMS who were treated in Pingdingshan First People’s Hospital from January 2019 to June 2020 were selected,and they were divided into control group and observation group by random number table method,with 58 cases in each group.Patients in control group were given gestrinone for postoperative adjuvant treatment,and patients in observation group received GnRH-αfor postoperative adjuvant treatment.The levels of sex hormones,including estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH),and quality of life assessed by Endometriosis Health Profile-5(EHP-5)score were compared between the two groups before treatment and after 6 months of treatment.The incidence of perimenopausal symptoms,adverse drug reactions and recurrence were compared between the two groups during 6 months of treatment.Results After 6 months of treatment,the levels of E2,LH,FSH,and scores of EHP-5 in the two groups were decreased,compared with those before treatment,and the levels and scores of observation group were lower than those of control group(P<0.05).During 6 months of treatment,there was no significant difference in the incidence of perimenopausal symptoms and adverse drug reactions between the two groups(P>0.05).The recurrence rate of observation group(0.00%,0/58)was lower than that of control group(6.89%,4/58),P<0.05.Conclusions Compared with gestrinone,GnRH-αcan achieve a more significant efficacy in the adjuvant treatment of patients with EMS after laparoscopic surgery,and it can help to regulate the levels of sex hormones,reduce postoperative recurrence,and effectively improve the quality of life.In addition,it can ensure the safety of medication.

关 键 词：子宫内膜异位症 促性腺激素释放激素激动剂 孕三烯酮 术后辅助治疗 性激素 

分 类 号：R713.4[医药卫生—妇产科学]