Genome-wide signatures of mammalian skin covering evolution  

作　　者：Peng Cao Qinlong Dai Cao Deng Xiang Zhao Shishan Qin Jian Yang Ran Ju Zhiwen Wang Guoqing Lu Xiaodong Gu Zhisong Yang Lifeng Zhu 

机构地区：[1]Key Laboratory of Drug Targets and Drug Leads for Degenerative Diseases,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China [2]College of Life Sciences,Nanjing Normal University,Nanjing 210046,China [3]University of Nebraska at Omaha,Omaha 68181,USA [4]DNA Stories Bioinformatics Center,Chengdu 610021,China [5]PubBio-Tech Services Corporation,Wuhan 430070,China [6]Sichuan Station of Wildlife survey and Management,Chengdu 610082,China [7]Nanjing Foreign Language School Xianlin Branch,Nanjing 210023,China [8]Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of Education),China West Normal University,Nanchong 637002,China [9]Shimian Research Center of Giant Panda Small Population Conservation and Rejuvenation,Yaan 625400,China [10]Liziping Natural Reserve,Yaan 625400,China

出　　处：《Science China(Life Sciences)》2021年第10期1765-1780,共16页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Fund for Outstanding Youth Fund(31222009,31272295,31570489,81622048 and 81473377);the Project of Quality Guarantee System of Chinese Herbal Medicines(201507002);Science Foundation for Distinguished Young Scholars of Jiangsu Province(BK20140049);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).

摘　　要：Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat,ultraviolet radiation,water loss,and mechanical forces.Here,using a comparative genomics analysis of 39 mammal species spanning three skin covering types(hairless,scaly and spiny),we found some genes(e.g.,UVRAG,POLH,and XPC)involved in skin inflammation,skin innate immunity,and ultraviolet radiation damage repair were under selection in hairless ocean mammals(e.g.,whales and manatees).These signatures might be associated with a high risk of skin diseases from pathogens and ultraviolet radiation.Moreover,the genomes from three spiny mammal species shared convergent genomic regions(EPHB2,EPHA4,and NIN)and unique positively selected genes(FZD6,INVS,and CDC42)involved in skin cell polarity,which might be related to the development of spines.In scaly mammals,the shared convergent genomic regions(e.g.,FREM2)were associated with the integrity of the skin epithelium and epidermal adhesion.This study identifies potential convergent genomic features among distantly related mammals with the same skin covering type.

关 键 词：comparative genomics skin coverings spiny mammals hairless mammals scaly mammals convergent evolution 

分 类 号：Q953[生物学—动物学]