miR-146a参与不同疾病的研究进展  

Research Progress on miR-146a Involved in Different Diseases

作　　者：朱嘉豪 陈婷 习欠云[1] ZHU Jia-hao;CHEN Ting;XI Qian-yun(National Engineering Research Center for Breeding Swine Industry/Key Laboratory of Animal Nutrition Control in Guangdong,College of Animal Science,South China Agricultural University,Guangzhou 510642,China)

机构地区：[1]华南农业大学动物科学学院,国家生猪种业工程技术中心,广东省动物营养调控重点实验室,广州510642

出　　处：《中国生物工程杂志》2021年第9期64-70,共7页China Biotechnology

基　　金：国家自然科学基金(31872435);国家“十三五”重点研发计划(2016YFD0500503);广东省自然科学基金重点资助项目(2018B030311015)资助项目。

摘　　要：miR-146a是近年来miRNA研究的热点,其在不同物种中高度保守,并参与了各种类型疾病的发生与发展,如炎症、自身免疫性疾病、癌症与肥胖症等,其机制主要通过TLR4、MyD88、NF-κB和Akt等信号通路来发挥作用。就miR-146a在不同疾病过程中的作用及其机制进行综述,为深入研究miR-146a在各类疾病中的调节作用提供资料。miR-146 a is a hot topic in recent miRNA study and keeps highly conserved in different species.It is involved in the occurrence and development of various types of diseases,such as inflammation,autoimmune diseases,cancer and obesity,and its mechanism mainly plays a role through TLR4,MyD88,NF-κB and Akt signaling pathways.In this paper,the roles and mechanisms of miR-146 a in different disease processes are reviewed to provide information for further research on the regulatory role of miR-146 a in various diseases.

关 键 词：MIR-146A 不同疾病 作用机制 

分 类 号：Q527[生物学—生物化学]