Cobalt-catalyzed atom-economical, diastereo-and enantioselective coupling of aldimines and cyclopropanols  

作　　者：Zhikun Liang Qinglei Chong Fanke Meng 

机构地区：[1]State Key Laboratory of Organometallic Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Science China Chemistry》2021年第10期1750-1755,共6页中国科学（化学英文版）

基　　金：the National Natural Science Foundation of China (21702222, 21821002, 92056103);Shanghai Rising-Star Program (19QA1411000)。

摘　　要：Catalytic generation of cobalt enolates through ring-opening of easily accessible cyclopropanols, subsequent β-hydride elimination and site-selective reinsertion followed by diastereo-and enantioselective additions to aldimines is presented. Such a process represents an unprecedented reaction pathway of cobalt homoenolates, affording a wide range of β-amino-ketones in up to 95% yield, 90:10 dr and 99:1 er without the need of any stoichiometric amount of additive or reagent.

关 键 词：COBALT enantioselective catalysis HOMOENOLATE Mannich reaction cyclopropanol 

分 类 号：O621.251[理学—有机化学]