黄芩苷抗炎作用机制的研究进展  

Progress in Anti-inflammatory Mechanism of Baicalin

作　　者：周颖 张珂 庄煜 胡国良 ZHOU Ying;ZHANG Ke;ZHUANG Yu;HU Guoliang(Jiangxi Provincial Key Laboratory for Animal Health,Institute of Animal Population Health,College of Animal Science and Technology,Jiangxi Agricultural University,Nanchang 330045,China)

机构地区：[1]江西农业大学动物科学技术学院,江西省畜禽疫病诊断与防控重点实验室,江西农业大学动物群发性疾病检测和防治研究所,南昌330045

出　　处：《激光生物学报》2021年第5期400-405,共6页Acta Laser Biology Sinica

基　　金：国家自然科学基金项目(32060819)。

摘　　要：黄芩苷(baicalin)是由黄芩(Scutellaria baicalensis Georgi)根部分离而来的黄酮类物质,为黄芩的主要活性成分。黄芩苷药理作用广泛,具有良好的抗炎效果,其主要机制包括调节肠道菌群、抑制核因子κB(NF-κB)核转位、增加相关microRNA的表达、抑制自噬、调节Treg/Th17平衡等。现综述黄芩苷抗炎症作用机制的最新研究进展,为其深入研究及在临床上的应用提供依据。Baicalin,a kind of flavonoid substance derived from the root part of Scutellaria baicalensis Georgi,which is the main active ingredient of the plant.The pharmacological effect of baicalin is extensive and it shows great potential in its anti-inflammatory effect,and its main mechanisms include regulating intestinal flora,inhibiting NF-κB nuclear transposing,increasing the expression of related microRNA,inhibiting autophagy,and regulating Treg/Th17 balance.This article reviewed the research progress of baicalin on the anti-inflammatory mechanism at home and abroad,which provides a basis for its clinical application and further study.

关 键 词：黄芩苷 炎症 肠道菌群 NF-ΚB MIRNA 

分 类 号：R97[医药卫生—药品]