胆囊收缩素及其受体的研究进展  

Research progress of cholecystokinin and its receptor

作　　者：李秋菊(综述) 王丰(审校) LI Qiuju;WANG Feng(Graduate School of Tianjin Medical University,Tianjin 300070,China;Tianjin Key Laboratory of Acute Abdominal Organ Injury and Intergrated Traditional Chinese and western Medicine Repair,Tianjin 300100,China)

机构地区：[1]天津医科大学研究生学院,300070 [2]天津市急腹症器官损伤与中西医结合修复重点实验室,300100

出　　处：《重庆医学》2021年第20期3571-3575,共5页Chongqing medicine

基　　金：国家自然科学基金项目(81572318)。

摘　　要：胆囊收缩素(CCK)作为一种肽类激素,在与靶细胞的CCK受体(CCKR)结合后调节消化系统、心血管系统和神经系统的多项功能。在消化系统中,受CCK调节的功能包括胆囊收缩、胰酶分泌、胰腺生长和胃肠蠕动等;而在心血管系统中,CCK参与心率和血压的调节;在神经系统中,CCK则作为神经递质,在进食、疼痛、体温及情绪等方面发挥调节作用。近年来的研究表明,CCK和CCKR与肿瘤密切相关,对其深入研究将有助于寻找肿瘤的治疗靶点,并设计出针对独特靶点的药物,进而为相关肿瘤的治疗开辟道路。As a peptide hormone,cholecystokinin(CCK)regulates multiple functions of the digestive system,cardiovascular system and nervous system through binding to the CCK receptor(CCKR)of target cells.In the digestive system,the functions regulated by CCK include gallbladder contraction,pancreatic enzyme secretion,pancreatic growth and gastrointestinal peristalsis.In the cardiovascular system,CCK participates in the regulation of heart rate and blood pressure.In the nervous system,CCK acts as an important neurotransmitter,which plays a regulatory role in eating,pain,body temperature and mood.Research in recent years has shown that CCK and CCKR are closely related to tumors.In depth research on them will help to find therapeutic targets for tumors and design drugs for unique targets,thereby opening the way for the treatment of related tumors.

关 键 词：胆囊收缩素 胆囊收缩素受体 胃肠道 心血管 神经递质 肿瘤 

分 类 号：R341[医药卫生—基础医学]