辅酶Q10对冠心病介入术后心功能恢复的作用研究  

Effect of coenzyme Q10 on cardiac function recovery in patients with coronary heart disease after percutaneous coronary intervention

作　　者：孟帅 金泽宁[2] Meng Shuai;Jin Zening(Department of Cardiology,Beijing Tiantan Hospital,Capital Medical University,Beijing,100070,China;不详)

机构地区：[1]首都医科大学附属北京天坛医院心内科,北京100070 [2]首都医科大学附属北京安贞医院心内三科,北京100029

出　　处：《中国循证心血管医学杂志》2021年第10期1217-1220,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：首都医科大学附属北京天坛医院青年基金课题(YZR-2020-10);2019年度科研培育基金课题(PYZ19093)。

摘　　要：目的探讨辅酶Q10(CoQ10)对冠状动脉粥样硬化性心脏病(冠心病)介入术后心功能恢复的作用。方法将北京安贞医院于2017年8月至2018年8月收治的79例老年冠心病患者随机分为对照组和研究组。对照组40例,予冠心病常规治疗,研究组39例,给予冠心病常规治疗联合辅酶Q10进行治疗,均治疗6个月,观察两组患者的临床疗效、心功能指标[左室射血分数(LVEF)、左室收缩末期容积(LVESV)、左室收缩末期内径(LVESD)及左室舒张末期内径(LVEDD)]、治疗前及治疗1、3及6个月后凝血功能指标[(凝血酶原时间(PT)、纤维蛋白原(FIB)及血小板最大聚集率(MPAR)]、治疗前后血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)及白细胞介素-6(IL-6)水平及不良反应发生情况。结果研究组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。两组患者在治疗6个月后,LVEF均显著升高,而LVEDD、LVESD、LVESV均显著降低,治疗后研究组的心功能指标显著优于对照组,差异具有统计学意义(P<0.05);两组患者在治疗1、3及6个月后,PT、FIB均显著升高(P<0.05),MPAR显著降低(P<0.05),且研究组优于对照组(P<0.05)。继续治疗至6个月与治疗3个月时的凝血功能指标无显著性差异;两组患者在治疗后血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)及白细胞介素-6(IL-6)水平均降低,且研究组优于对照组,差异有统计学意义(P<0.05);两组患者治疗期间均未发生严重的不良反应。结论辅酶Q10对冠心病介入术后的心功能恢复作用显著,对于改善患者临床症状具有积极意义,有利于指导临床治疗。Objective To discuss the effect of coenzyme Q10(CoQ10)on cardiac function recovery in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods The elderly patients with CHD(n=79)were chosen from Beijing Tiantan Hospital of Capital Medical University from Aug.2017 to Aug.2018,and divided randomly into control group and research group.The control group(n=40)were treated with routine therapy for CHD,and research group(n=39)were additionally given Q10 for 6 months.The clinical efficacy and heart function indexes including LVEF,LVESV,LVESD and LVEDD were observed in 2 groups.The coagulation function indexes including prothrombin time(PT),fibrinogen(FIB)and maximum platelet aggregation rate(MPAR)before and after treatment for 1 month and 3 and 6 months,hs-CRP,TNF-α and IL-6 before and after treatment,and adverse reactions were observed in 2 groups.Results The total effective rate was higher in research group than that in control group(P<0.05).After treatment for 6 months,LVEF increased significantly,and LVEDD,LVESD and LVESV decreased significantly in 2 groups,and heart function indexes were significantly superior in research group than those in control group(P<0.05).PT and FIB increased significantly(P<0.05)and MPAR decreased significantly(P<0.05)in 2 groups,which was superior in research group than those in control group(P<0.05)after treatment for 1 month and 3 and 6 months.The coagulation function indexes had no significant difference in 2 groups after continued treatment for 6 months compared with those after 3 months.The levels of hs-CRP,TNF-αand IL-6 decreased in 2 groups after treatment,which was more significant in research group compared with control group(P<0.05).There were no severe reverse reactions observed in 2 groups during treatment.Conclusion CoQ10 has significant effect on cardiac function recovery in CHD patients after PCI,can relieve clinical symptoms and helpful for guiding clinical treatment.

关 键 词：辅酶Q10 冠心病介入 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]