系统性红斑狼疮中干扰素的表观遗传学研究进展  

Research progress on epigenetics of interferon in systemic lupus erythematosus

作　　者：沈梦佳 王涛[1,2] 李志军 吴华勋[3] SHEN Meng-jia;WANG Tao;LI Zhi-jun;WU Hua-xun(Dept of Rheumatology and Immunology, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004,China;Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu 233030, China;Institute of Clinical Pharmacology of Anhui Medical University, Hefei 230032, China)

机构地区：[1]蚌埠医学院第一附属医院风湿免疫科,安徽蚌埠233004 [2]慢性疾病免疫学基础与临床安徽省重点实验室,安徽蚌埠233030 [3]安徽医科大学临床药理研究所,安徽合肥230032

出　　处：《中国药理学通报》2021年第11期1507-1511,共5页Chinese Pharmacological Bulletin

基　　金：国家高技术研究发展计划(863计划)子课题(No012AA02A513);安徽省高等学校省级质量工程项目(No2018jyxm0832,2020jyxm0882)。

摘　　要：系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种以自身抗原免疫耐受崩溃、大量自身抗体产生为主要特点的自身免疫性疾病,临床表现多样,发病机制复杂。干扰素(interferon,IFN)信号通路是其目前广泛认同的致病通路之一,近年来关于IFN信号及通路和表观遗传修饰的相互关系在SLE疾病发生发展中所发挥的作用受到广泛的重视。该文就相关研究做一综述,以期为SLE的发病机制提供新的研究思路。Systemic lupus erythematosus(SLE)is an autoimmune disease with various clinical manifestations and complex pathogenesis,characterized by loss of immune tolerance to autoantigens and production of large amounts of autoantibodies.Interferon(IFN)signaling pathway is one of the pathogenetic pathways widely recognized at present.In recent years,the correlation between IFN signaling and epigenetic modification in the occurrence and development of SLE has beena research hotspot.And in this paper,the relevant studies are reviewed in order to provide new research ideas for the pathogenesis of SLE.

关 键 词：系统性红斑狼疮 干扰素 表观遗传学 DNA甲基化 组蛋白修饰 非编码RNA 

分 类 号：R392.11[医药卫生—免疫学] R394.3[医药卫生—基础医学]