强迫症患者大脑灰质体积变化——基于体素的形态学分析  

Gray matter abnormalities in obsessive-compulsive disorder by voxel-based morphometry research

作　　者：李若川 唐洁 杨勇锋[3] 樊令仲[2] 张海东 LI Ruo-chuan;TANG Jie;YANG Yong-feng;FAN Ling-zhong;ZHANG Hai-dong(School of Basic Medicine,Shandong First Medical University(Shandong Academy of Medical Sciences),Ji’nan 250000,China;Institute of Automation,Chinese Academuy of Sciences,Beijing 100190,China;He’nan Key Laboratory of Biological Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,He’nan Xinxiang 453002,China;School of Clinical Medicine,Shandong First Medical University(Shandong Academy of Medical Sciences),Ji’nan 250000,China)

机构地区：[1]山东第一医科大学(山东省医学科学院)基础医学院,济南250000 [2]中国科学院自动化研究所,北京100190 [3]新乡医学院第二附属医院河南省生物精神病重点实验室,河南新乡453002 [4]山东第一医科大学(山东省医学科学院)临床医学院,济南250000

出　　处：《解剖学报》2021年第5期692-697,共6页Acta Anatomica Sinica

基　　金：山东省自然科学基金(ZR2017LH052);山东省大学生创新创业计划项目(S201910439138);山东第一医科大学大学生科研计划项目(201901012)。

摘　　要：目的探讨强迫症(OCD)患者大脑灰质体积的变化,并分析其在发病过程中可能存在的相关机制。方法选择31例年龄17~47岁重度强迫症患者和31例正常对照被试者,获取脑结构磁共振T1图像,使用基于体素的形态学测量(VBM)方法,比较强迫症组和对照组大脑灰质体积的差异,并将患者灰质体积差异区与其临床评分进行相关分析。结果与对照组相比,OCD患者在左侧壳核、岛叶、运动前区、顶上小叶以及右侧角回处体积显著减小。左侧壳核和岛叶的体积与患者贝克焦虑量表(BAI)评分成显著负相关。结论左侧壳核、岛叶、运动前区、顶上小叶以及右侧角回的灰质体积变化影响了该脑区功能,从而导致了OCD患者的部分症状。其中左侧壳核以及岛叶的损伤与患者焦虑情绪的异常密切相关。Objective To investigate the abnormalities of gray matter volume in obsessive-compulsive disorder(OCD)patients relative to controls using the method of voxel-based morphometry(VBM),and to analyze the extent of change relative to clinical symptom.Methods Using VBM to compare the MRI images of 31 adult OCD patients with 31 healthy controls.Correlation analyses were conducted between the structural abnormalities of gray matter volume in each brain area among patients relative to their clinical scores.Results Compared with the healthy controls,the OCD patients showed reductions of gray matter volume in left putamen,insula,premotor area,superior parietal and right angular gyrus(P<0.01,Alphasim corrected).The gray matter volumes of left putamen and insular in the OCD patients showed a negative correlation with the Beck anxiety inventory(BAI)scores.Conclusion The changes in gray matter volumes of left putamen,insula,premotor area,superior parietal lobule and right angular gyrus may be related to the pathogenesis of OCD.The declines of left putamen and insula are related to the abnormal anxiety in the OCD patients.

关 键 词：强迫症 灰质体积 基于体素的形态学测量 磁共振成像 人 

分 类 号：R395.1[哲学宗教—心理学]