锡粉促进下喹喔啉酮类化合物的二氟甲基化反应研究  

Study on Difluoromethylation of Quinoxalinone Compounds Promoted by Tin Powder

作　　者：柴丽 王克虎[1] CHAI Li;WANG Ke-hu(College of Chemistry and Chemical Engineering,Northwest Normal University,Gansu Lanzhou 730070,China)

机构地区：[1]西北师范大学化学化工学院,甘肃兰州730070

出　　处：《广州化工》2021年第20期20-22,共3页GuangZhou Chemical Industry

摘　　要：探索了在锡粉促进下,以溴二氟乙酸乙酯作为二氟亚甲基合成砌块,由喹喔啉-2(1H)-酮"一锅法"合成3-二氟亚甲基-3,4-二氢喹喔啉-2(1H)-酮类衍生物。反应的最优条件为:78℃回流;喹喔啉-2(1H)-酮,溴二氟乙酸乙酯,锡粉的摩尔比为1:2:2.5,添加剂为三氟化硼乙醚(2倍当量),溶剂为四氢呋喃。该法为合成3-二氟亚甲基-3,4-二氢喹喔啉-2(1H)-酮类化合物提供了一种新方法。“One-pot”synthesis of 3-difluoromethyl-3,4-dihydroquinoxaline-2(1H)-ones was explored using ethyl bromodifluoroacetate as difluoromethylation building block promoted by tin powder.The optimum reaction conditions were as following:reflux at 78℃,the molar ratio of quinoxaline-2(1H)-one,ethyl bromodifluoroacetate and tin powder was 1􀏑2􀏑2.5,the additive was BF3·Et_(2)O(2 equivalent),and the solvent was tetrahydrofuran.The method provided a new method for the synthesis of 3-difluoromethyl-3,4-dihydroquinoxaline-2(1H)-one derivatives.

关 键 词：亲核加成反应 3 4-二氢喹喔啉-2(1H)-酮 溴二氟乙酸乙酯 锡粉 

分 类 号：O626.4[理学—有机化学]