Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization  

作　　者：Yongcun Qu Qi Chen Shanshan Guo Chiyuan Ma Yonggang Lu Junchao Shi Shichao Liu Tong Zhou Taichi Noda Jingjing Qian Liwen Zhang Xili Zhu Xiaohua Lei Yujing Cao Wei Li Wei Li Nicolas Plachta Martin M.Matzuk Masahito Ikawa Enkui Duan Ying Zhang Hongmei Wang 

机构地区：[1]State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Division of Biomedical Sciences,School of Medicine,University of California,Riverside,CA 92521,USA [4]Research Institute for Microbial Diseases,Osaka University,Suita,Osaka,Japan [5]Department of Physiology and Cell Biology,Reno School of Medicine,University of Nevada,Reno,NV,USA [6]Institute of Molecular and Cell Biology,A*STAR,Singapore,Sin gapore [7]Center for Drug Discovery,Department of Pathology and Immunology,Baylor College of Medicine,Houston,TX 77030,USA [8]Division of Biology and Biological Engineering,California Institute of Technology,Pasadena,CA,USA [9]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China [10]The Key Laboratory of Cell Proliferation and Regulation Biology,Ministry of Education,Institute of Cell Biology,Beijing Normal University,Beijing 100875,China

出　　处：《Protein & Cell》2021年第10期810-817,共8页蛋白质与细胞（英文版）

基　　金：This work was supported by the National Key Research and Development Program of China(2018YFC1004500 to YZ,2019YFA0802600 to YZ,2016YFA0500903 to ED,2017YFC1001401 to ED,2015CB943003 to YZ);the Strategic Priority Research Program of the CAS(XDA16020700 to HW)National Basic Research Program of China(81490742 to ED);National Natural Science Foundation of China(81490741 to HW,31671201 to YZ,31671568 to ED);Youth Inn ovation Promotion Association,CAS(Grant No.2016081 to YZ);The Eunice Kennedy Shriver Nation al Institute of Child Health and Human Development(grants HD088412 and P01HD087157)supports our studies of UTJ migration defects in mouse models.

摘　　要：Dear Editor,Sperm cooperation has been observed in multiple species(Pizzari and Foster,2008),yet its existenee and benefit for reproductive success in mammals remains underexplored.Here,combining tissue-clearing with deep three-dimensional(3D)imagi ng,we dem on strate that postcopulatory mouse sperm congregate into unidirectional sperm cooperative clusters at the utero-tubal junction(UTJ),a key physical barrier for passage into the oviduct.

关 键 词：PASSAGE media FOSTER 

分 类 号：Q2[生物学—细胞生物学]