颞叶癫痫及合并认知障碍患者的中医体质研究  

TCM constitution of patients with temporal lobe epilepsy and cognitive impairments

作　　者：吴犀翎[1,2] 黄小波 刘爱华[1] 陈玉静 刘妍[1,2] 王倩[1,2] 王建东 魏岚[1] Wu Xiling;Huang Xiaobo;Liu Aihua;Chen Yujing;Liu Yan;Wang Qian;Wang Jiandong;Wei Lan(Xuanwu Hospital,Capital Medical University,Beijing 100053;Beijing Institute of Geriatric Diseases with Integrated Traditional Chinese and Western Medicine)

机构地区：[1]首都医科大学宣武医院,北京100053 [2]北京市中西医结合老年疾病研究所

出　　处：《现代中医临床》2021年第5期24-27,共4页Modern Chinese Clinical Medicine

基　　金：北京市中医药科技项目(No.QN2018-16);北京市中西医结合老年疾病研究所专项(No.2012-191);国家重点研发计划资助项目(No.2018YFC1312002)。

摘　　要：目的研究颞叶癫痫患者的认知功能状况及其与中医体质类型的相关性。方法纳入首都医科大学宣武医院神经内科病房和中医科门诊确诊的颞叶癫痫患者98例,与正常组30例进行比较。观察蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评分和中医体质分布。结果颞叶癫痫患者的MoCA评分总分和视空间执行力、注意力、语言能力、延迟记忆能力子项目评分低于正常组(P<0.01)。颞叶癫痫组较正常组相比气虚质和湿热质的患者多于其他体质(P<0.05);颞叶癫痫患者中认知正常者平和质多于其他体质(P<0.01),合并认知障碍者气虚质多于其他体质(P<0.05)。结论颞叶癫痫患者的认知功能降低明显,体现在视空间执行力、注意力、语言能力、延迟记忆能力等方面。从中医的9种体质比较,颞叶癫痫气虚质和湿热质患者多见,颞叶癫痫气虚质患者更易合并认知障碍。Objective To observe the cognitive function in patients with temporal lobe epilepsy(TLE),and to explore the correlation between TCM constitution types and TLE and their cognitive function.Methods A total of 98 TLE patients were enrolled for cognitive tests and TCM constitution types tests,from the neurology ward and outpatient of TCM Department at Xuanwu Hospital of Capital Medical University from October 2018 to January 2020.Montreal Cognitive Assessment(MoCA)scores and TCM constitution types between the TLE group and normal group(n=30)were observed.Results There were significantly lower scores in MoCA and visuospatial and executive,memory,attention,language in patients with TLE(P<0.01).As compared with the normal group,patients with the constitution of qi deficiency and with the dampness-heat constitution outnumbered those with other types in the TLE group(P<0.05).In the TLE group with normal cognitive ability,patients with the peaceful constitution outnumbered those with other types(P<0.01);in the TLE group with the cognitive impairments,the qi deficiency constitution was more than other types(P<0.05).Conclusions The cognitive function of patients with TLE was significantly reduced,which was reflected in visuospatial and executive ability,attention,language ability and memory.From the comparison of the nine TCM constitutions,qi deficiency and dampness-heat constitutions are more common in patients with TLE,and qi deficiency patients are more likely to suffer cognitive impairments.

关 键 词：颞叶癫痫 认知障碍 蒙特利尔认知评估量表 中医体质 

分 类 号：R259[医药卫生—中西医结合]