德谷胰岛素结合门冬胰岛素在2型糖尿病患者治疗中的效果分析  

Effect analysis of insulin degludec combined with insulin aspart in patients with type 2 diabetes mellitus

作　　者：王倩 WANG Qian(Fushun Staff Sanatorium,Fushun 113000,China)

机构地区：[1]抚顺市职工疗养院,113000

出　　处：《中国实用医药》2021年第29期130-133,共4页China Practical Medicine

摘　　要：目的分析德谷胰岛素结合门冬胰岛素在2型糖尿病患者治疗中的效果。方法180例2型糖尿病患者,采用随机单双数法分为对照组和观察组,每组90例。对照组患者给予胰岛素结合二甲双胍治疗,观察组患者给予德谷胰岛素结合门冬胰岛素治疗。对比两组患者治疗前及治疗后2周血糖指标[空腹血糖、餐后2 h血糖、糖化血红蛋白(HbA1c)]、血糖达标时间、平均血糖波动幅度。结果治疗后2周,观察组患者空腹血糖、餐后2 h血糖、HbA1c水平均低于对照组,差异具有统计学意义(P<0.05)。观察组患者血糖达标时间(7.26±1.46)d短于对照组的(8.16±1.78)d,平均血糖波动幅度(2.14±0.35)mmol/L低于对照组的(3.60±0.42)mmol/L,差异具有统计学意义(P<0.05)。结论为2型糖尿病患者采用德谷胰岛素结合门冬胰岛素治疗不仅可有效控制血糖水平,同时也可缩短血糖达标时间,降低血糖波动幅度,值得临床推广应用。Objective To analyze the effect of insulin degludec combined with insulin aspart in patients with type 2 diabetes mellitus.Methods A total of 180 patients with type 2 diabetes mellitus were divided into control group and observation group according to random odd-even number method,with 90 cases in each group.Patients in the control group were treated with insulin combined with metformin,and patients in the observation group were treated with insulin degludec and insulin aspart.Patients in both groups were compared in terms of blood glucose indexes[fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin(HbA1c)]before treatment and 2 weeks after treatment,blood glucose control time,mean amplitude of glycemic excuisions.Results Before treatment,there was no statistically significant difference in fasting blood glucose,2 h postprandial blood glucose and HbA1c levels between the two groups(P>0.05).2 weeks after treatment,the fasting blood glucose,2-h postprandial blood glucose and HbA1c levels of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).In the observation group,the blood glucose control time(7.26±1.46)d was shorter than(8.16±1.78)d in the control group,and the mean amplitude of glycemic excuisions(2.14±0.35)mmol/L was lower than(3.60±0.42)mmol/L in the control group.All the differences were statistically significant(P<0.05).Conclusion Combination in insulin degludec and insulin aspart for patients with type 2 diabetes mellitus can not only effectively control the blood glucose level,but also shorten the blood glucose control time and reduce the amplitude of glycemic excuisions,which is worthy of clinical promotion and application.

关 键 词：德谷胰岛素 门冬胰岛素 二甲双胍 餐后血糖 

分 类 号：R587.1[医药卫生—内分泌]