神效散巴布剂的体外透皮吸收研究  

Transdermal absorption of Shenxiao Powder Cataplasm

作　　者：王爱国 谷福顺[2] 郑昆仑[2] 陆军 赵允[1] 王晓辉[3] WANG Ai-guo;GU Fu-shun;ZHENG Kun-lun;LU Jun;ZHAO Yun;WANG Xiao-hui(Affiliated Hospital of Tianjin Academy of TCM,Tianjin 300120,China;Second Affiliated Hospital of Tianjin University of TCM,Tianjin 300250,China;Tianjin Institute of Medical and Pharmaceutical Sciences,Tianjin 300020,China)

机构地区：[1]天津市中医药研究院附属医院,天津300120 [2]天津中医药大学第二附属医院,天津300250 [3]天津市医药科学研究所,天津300020

出　　处：《现代药物与临床》2021年第9期1812-1816,共5页Drugs & Clinic

基　　金：天津市中医药重点领域科研项目(2017007);天津市中医药研究院附属医院院内科研基金资助项目(2020004)。

摘　　要：目的比较神效散散剂和巴布剂的透皮吸收效果。方法采用HPLC法测定神效散散剂和巴布剂中血竭素、三七皂苷R_(1)。使用扩散池装置,以离体小鼠皮肤为屏障进行体外透皮吸收研究,比较神效散巴布剂和散剂中血竭素、三七皂苷R_(1)的累积渗透量、渗透速率。结果神效散散剂和巴布剂中血竭素、三七皂苷R_(1)累积渗透量随着时间的增加而增大,且两种成分的累积渗透量:巴布剂>散剂;渗透速率:巴布剂>散剂。结论与神效散散剂比较,神效散巴布剂具有更强的透皮吸收效果。Objective To evaluate the transdermal absorption effect of Shenxiao Powder Cataplasm. Methods Dracorhodin and notoginseng saponin R_(1) in Shenxiao Powder Cataplasm and Shenxiao Powder were determined. Diffusion cell device was used, and in vitro transdermal absorption was studies with isolated mouse skin as a barrier. The cumulative penetration and penetration rate of dracorhodin and notoginseng saponin R_(1) in Shenxiao Powder Cataplasm and Shenxiao Powder were compared. Results The cumulative penetration of the two dosage forms were increased with the increase of time, and the cumulative penetration of the two main components was: cataplasm > powder;Penetration rate: cataplasm > powder. Conclusion Compared with Shenxiao Powder,Shenxiao Powder Cataplasm has stronger transdermal absorption.

关 键 词：神效散巴布剂 神效散 血竭素 三七皂苷R_(1) 累积渗透量 渗透速率 高效液相色谱 

分 类 号：R286.02[医药卫生—中药学]