Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex  

作　　者：Sijie Huang Peiyu Xu Yangxia Tan Chongzhao You Yumu Zhang Yi Jiang H.Eric Xu 

机构地区：[1]The CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medico,Chinese Academy of Sciences,Shanghai,China [2]University of Chinese Academy of Sciences,Beijing,China [3]School of Life Science and Technology,ShanghaiTech University,Shanghai,China

出　　处：《Cell Research》2021年第9期1036-1038,共3页细胞研究（英文版）

基　　金：This work vyas partially supported by the Ministry of Science and Technology of China(2018YFA0507002 to HEX);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37030103 to HEX);Shanghai Municipal Science and Technology Major Project(2019SHZDZX02 to HEX);the National Natural Science Foundation of China(31770796 to YJ);National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program"(2018ZX09711002-002-002 to YJ).

摘　　要：Dear Editor,The serotonin 5-HTt receptor subtypes,including 5-HT_(1A)/5-HT_(1B)/5-HT_(1D),5-HT_(1E),and 5-HT_(1F),are G protein-coupled receptors(GPCRs)that respond to the endogenous neurotransmitter serotonin and couple preferentially to the G_(i/o)family of G proteins.

关 键 词：SEROTONIN ENDOGENOUS MIGRAINE 

分 类 号：R96[医药卫生—药理学]