A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction  

作　　者：Suzanne J F Kaptein 

机构地区：[1]不详

出　　处：《四川生理科学杂志》2021年第8期1459-1459,共1页Sichuan Journal of Physiological Sciences

摘　　要：Dengue virus causes approximately 96 million symptomatic infections annually,manifesting as dengue fever or occasionally as severe dengue1,2.There are no antiviral agents available to prevent or treat dengue.Here,we describe a highly potent dengue virus inhibitor(JNJ-A07)that exerts nanomolar to picomolar activity against a panel of 21 clinical isolates that represent the natural genetic diversity of known genotypes and serotypes.The molecule has a high barrier to resistance and prevents the formation of the viral replication complex by blocking the interaction between two viral proteins(NS3 and NS4B),thus revealing a previously undescribed mechanism of antiviral action.

关 键 词：NS4B INTERACTION annually 

分 类 号：R51[医药卫生—内科学]