聚2-丙烯酰胺基-2-甲基丙磺酸催化合成β-吲哚酮  

SYNTHESIS OFβ-INDOLYLKETONES CATALYZED BY POLY(2-ACRYLAMIDO-2-METHYLPROPANESULFONIC ACID)

作　　者：赵志浩 代红光[1] 师兰 ZHAO Zhihao;DAI Hongguang;SHI Lan(College of Science,Inner Mongolia Agricultural University,Hohhot 010018,China)

机构地区：[1]内蒙古农业大学理学院,呼和浩特010018

出　　处：《内蒙古农业大学学报（自然科学版）》2021年第4期108-113,共6页Journal of Inner Mongolia Agricultural University(Natural Science Edition)

基　　金：国家自然科学基金项目(21607085)。

摘　　要：在催化剂的作用下,吲哚与苯亚甲基苯乙酮发生Michael加成反应,生成β-吲哚酮。本文以聚2-丙烯酰胺基-2-甲基丙磺酸(PAMPS)为该反应的非均相催化剂,系统研究了PAMPS的交联度、粒径、用量等对于反应的催化影响以及PAMPS回收循环使用及活化再生对反应的影响。研究发现苯亚甲基苯乙酮上连有吸电子取代基比连有给电子取代基活性高。所得β-吲哚酮产率67%~93%。PAMPS催化剂具有活性高、价廉易得、易于回收且对环境友好等特点。β-Indolylketones were synthesized by the Michael addition reaction of the indole and benzylidene acetophenones by using the poly(2-acrylamido-2-methylpropanesulfonic acid)(PAMPS)as the heterogeneous catalyst.The influences of the PAMPS crosslinking degree,particle size,and amount on the catalytic effect were studied.The recycling experiments and activation of PAMPS were systemically studied.The benzylidene acetophenone with the electron-withdrawing group was more active than that with the electron-donating group.The yields ofβ-indolylketones were from 67%to 93%.PAMPS was an cost-effective,readily available,and environmentally friendly catalyst with high catalytic activity.

关 键 词：杂环化合物 MICHAEL加成 多相催化 

分 类 号：TQ426.7[化学工程]