养肝益水颗粒对阴虚阳亢型原发性高血压患者血压变异性、血管内皮功能和尿蛋白的影响  

Effect of Yanggan Yishui Granule on Blood Pressure Variability,Vascular Endothelial Function and Urinary Protein in Patients with Hypertension of Yin Deficiency Yang Hyperactivity Type

作　　者：张蓓蓓 张叶祥 程晓昱 胡业彬 阮仔玄 ZHANG Beibei;ZHANG Yexiang;CHENG Xiaoyu;HU Yebin;RUAN Zixuan(Anhui University of Chinese Medicine Graduate School,Hefei 230031,China;不详)

机构地区：[1]安徽中医药大学研究生院,安徽合肥230031 [2]安徽中医药大学第一附属医院

出　　处：《中国医学创新》2021年第27期95-99,共5页Medical Innovation of China

基　　金：国家自然科学基金项目(81873038);安徽省卫生和计划生育委员会中医药领军人才培养对象专项项目(中医药发展秘[2018]23号);安徽省名中医工作室建设项目(中医药发展秘[2020]10号);安徽省高校自然科学研究重点项目(KJ2020A0400)。

摘　　要：目的:探讨养肝益水颗粒对阴虚阳亢型高血压患者血压变异性、血管内皮功能和尿蛋白的影响。方法:选取2019年10月-2020年12月本院就诊的80例辨证为阴虚阳亢型的高血压患者。根据随机数字法将其分为对照组和观察组,每组40例。对照组采用左旋氨氯地平片治疗,观察组在对照组基础上加用养肝益水颗粒。比较两组中医证候疗效及治疗前后的血压变异性、血管内皮功能和尿蛋白。结果:观察组总有效率为85.00%,高于对照组的65.00%,差异有统计学意义(P<0.05)。治疗前,两组24 h SBPV、24 h DBPV、DSBPV、DDBPV、NSBPV、NDBPV比较,差异均无统计学意义(P>0.05);治疗后,两组24 h DBPV、DSBPV、NSBPV均低于治疗前,观察组24 h SBPV、DDBPV均低于治疗前,差异均有统计学意义(P<0.05)。治疗后,两组NDBPV均低于治疗前,对照组24 h SBPV、DDBPV均低于治疗前,差异均无统计学意义(P>0.05)。治疗后,观察组24 h SBPV、24 h DBPV、DSBPV、NSBPV均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组DDBPV、NDBPV比较,差异均无统计学意义(P>0.05)。治疗前,两组ET-1、NO、24 h-UTP、UAER、β_(2)-MG比较,差异均无统计学意义(P>0.05);治疗后,两组ET-1、24 h-UTP、UAER、β_(2)-MG均低于治疗前,NO均高于治疗前,且观察组ET-1、24 h-UTP、UAER、β_(2)-MG均低于对照组,NO高于对照组,差异均有统计学意义(P<0.05)。结论:养肝益水颗粒辅助治疗阴虚阳亢型高血压患者具有良好的效果,可降低BPV,改善血管内皮功能,减少尿蛋白,值得推广应用。Objective:To explore the effect of Yanggan Yishui Granule on blood pressure variability,vascular endothelial function and urinary protein in patients with hypertension of yin deficiency yang hyperactivity type.Method:A total of 80 essential hypertension patients with yin deficiency yang hyperactivity type syndrome from October 2019 to December 2020 were selected,they were divided into control group and observation group according to random number method,40 cases in each group.The control group was treated with Levamlodipine Tablet,and the observation group was treated with Yanggan Yishui Granule on the basis of the control group.The effect of TCM syndrome was compared between two groups,blood pressure variability,vascular endothelial function and urinary protein before and after treatment were compared between two groups.Result:The total effective rate of observation group was 85.00%,which was higher than 65.00% of control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in 24 h SBPV,24 h DBPV,DSBPV,DDBPV,NSBPV and NDBPV between two groups(P>0.05).After treatment,24 h DBPV,DSBPV and NSBPV of both groups were lower than those before treatment,24 h SBPV and DDBPV of the observation group were lower than those before treatment,the differences were statistically significant(P<0.05).After treatment,NDBPV of both groups were lower than those before treatment,while 24 h SBPV and DDBPV of the control group were lower than those before treatment,the differences were not statistically significant(P>0.05).After treatment,the 24 h SBPV,24 h DBPV,DSBPV and NSBPV of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,there were no significant differences in DDBPV and NDBPV between two groups(P>0.05).Before treatment,there were no significant differences in ET-1,NO,24 h-UTP,UAER andβ_(2)-MG between two groups(P>0.05);after treatment,ET-1,24 h-UTP,UAER,β_(2)-MG of both groups

关 键 词：阴虚阳亢型 养肝益水颗粒 血压变异性 血管内皮功能 尿蛋白 

分 类 号：R544.1[医药卫生—心血管疾病]