MIIGX3硫酸钙骨水泥填充软骨下良性病变刮除后骨缺损的生物力学研究  

Biomechanical study of bone defects after curettage of benign subchondral lesions filled with MIIGX3 calcium sulfate bone cement

作　　者：刘旭剑[1] 王东来[1] 李增怀[1] 冯奇[1] 常富军[2] 冯建刚[1] LIU Xujian;WANG Donglai;LI Zenghuai;FENG Qi;CHANG Fujun;FENG Jiangang(the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;the 980th Hospital of PLA Joint Logistics Support Force,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第四医院,河北石家庄050011 [2]中国人民解放军联勤保障部队第980医院,河北石家庄050000

出　　处：《中国医学物理学杂志》2021年第10期1304-1307,共4页Chinese Journal of Medical Physics

基　　金：河北省医学科学研究重点课题(20170759)。

摘　　要：目的:探讨MIIGX3硫酸钙骨水泥填充软骨下良性病变刮除后骨缺损的生物力学特点。方法:选择20例股骨近端骨软骨瘤患者,病变刮除后采用MIIGX3硫酸钙骨水泥填充,X线定期对骨吸收和自体骨替代过程进行观察,于术后6和12个月,确保MIIGX3硫酸钙骨水泥完全吸收并被自体骨替代,采用中心旋转测力机测定术后不同时期患侧下肢生物力学特性。结果:20例患者手术成功,切口一期愈合,MIIGX3完全吸收并被自体骨替代,时间11~13周,平均(12.23±1.22)周;术后12个月巴氏评分高于术后6个月(P<0.05);术后12个月扭转1.5°时扭转刚度、扭转1.5°时扭矩、荷载800 N时压缩刚度均高于术后6个月,荷载800 N时压缩位移小于术后6个月,差异均具有统计学意义(P<0.05)。结论:MIIGX3硫酸钙骨水泥填充软骨下良性病变刮除后骨缺损生物力学表现较好,患者术后恢复情况及日常生活活动能力均较满意,适合推广。Objective To investigate the biomechanical characteristics of filling bone defects after curettage of benign subchondral lesions with MIIGX3 calcium sulfate cement.Methods Twenty patients with osteochondroma of the proximal femur were enrolled in the study.After curettage of the lesions,MIIGX3 calcium sulfate bone cement was used to fill the bone defects.The bone absorption and autologous bone replacement were observed by X-ray regularly.At 6 th months and 12 nd months after surgery,it was ensured that MIIGX3 calcium sulfate cement was absorbed completely and replaced by autogenous bone.The biological characteristics of the affected lower limbs of the two groups were measured using a central rotation dynamometer.Results The surgery was performed successfully in 20 patients.The patients recovered stably,and the incision was healed at the first stage.MIIGX3 was absorbed completely and replaced by autologous bone in 11-13 weeks,with an average of(12.23±1.22)weeks.The Barthel index at the 12nd month after surgery was higher than that at the 6th month after surgery(P<0.05);and moreover,compared with those at the 6th month after surgery,the torsional stiffness at 1.5°,the torque at 1.5°,and the compression stiffness at a load of 800 N were all higher at the 12nd month after surgery,but the compressive displacement at a load of 800 N was lower,and the differences were statistically significant(P<0.05).Conclusion Using MIIGX3 calcium sulfate bone cement to fill bone defects after curettage of benign subchondral lesions is suitable for promotion,because it has preferable biomechanical performance,and can achieve satisfactory postoperative recovery and activities of daily living.

关 键 词：MIIGX3硫酸钙骨水泥 软骨下良性病变 软骨瘤 股骨 生物力学 

分 类 号：R318.01[医药卫生—生物医学工程] R738.3[医药卫生—基础医学]