FEV_(1)%pred与SGRQ、mMRC、CAT评分在COPD患者中的相关性研究  

Relationship of FEV1%pred with SGRQ,mMRC and CAT in chronic obstructive pulmonary disease patients

作　　者：乔丽旻 张泽明 王静 毛建峰 陈昊 Qiao Limin;Zhang Zeming;Wang Jing;Mao Jianfeng;Chen Hao(Lian Yang Community Health Service Center of Shanghai Pudong New Area,Shanghai 200135,China;Department of Respiratory Medicine,Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital,Shanghai 201318,China)

机构地区：[1]上海市浦东新区联洋社区卫生服务中心,200135 [2]上海健康医学院附属周浦医院呼吸内科,201318

出　　处：《国际呼吸杂志》2021年第19期1493-1499,共7页International Journal of Respiration

基　　金：上海市卫生与计划生育委员会科研课题面上项目(201740310);浦东新区重点学科建设项目基金(PWZxK2017-22)。

摘　　要：目的研究慢性阻塞性肺疾病(COPD)患者第1秒用力呼气容积占预计值百分比(FEV_(1)%pred)同圣乔治呼吸问卷(SGRQ)、改良版英国医学研究委员会呼吸困难量表(mMRC)评分、慢性阻塞性肺疾病评估测试(CAT)评分的相关性。方法前瞻性研究。选取2019年1月至2020年1月在上海健康医学院附属周浦医院门诊以及联洋社区卫生服务中心门诊就诊的COPD患者68例。在预定时间随访,记录肺功能FEV_(1)%pred、SGRQ、mMRC评分及CAT评分测定结果,根据入组时COPD全球倡议分级进行分组,分为轻症组49例,重症组19例。分析3种评分系统和FEV_(1)%pred受时间变化的影响,使用Pearson相关性分析统计3种评分系统与FEV_(1)%pred之间的相关性。结果FEV_(1)%pred、SGRQ、mMRC评分比较组间·时点间比较,差异均无统计学意义(P值均>0.05)。除mMRC组间P>0.05外,其余的组间、时点间差异均有统计学意义(P值均<0.01)。总体FEV_(1)%pred、mMRC、CAT随时间变化差异均有统计学意义(P值均<0.05),SGRQ随时间变化差异无统计学意义(P>0.05)。FEV_(1)%pred、SGRQ、mMRC、CAT随访数据与入组数据比较,除FEV_(1)%pred第10个月和第13个月,CAT第7个月外,其余各组数据与入组第1个月差异均无统计学意义(P值均>0.05)。各随访时间点SGRQ与FEV_(1)%pred均呈负相关(P值均<0.01),在第1、13个月FEV_(1)%pred与mMRC呈负相关(P值均<0.05),第1、4、7、13个月FEV_(1)%pred与CAT呈负相关(P值均<0.05)。结论CAT评分和SGRQ均可以反映患者的肺功能,但在实际临床工作中,CAT评分的适用性可能比SGRQ更强。Objective To analyze the associations of forced expiratory volume in the first second in percent predicted values(FEV_(1)%pred),St George′s respiratory questionnaire(SGRQ),modified Medical Research Council(mMRC)and COPD Assessment Test(CAT)Scores in chronic obstructive pulmonary disease(COPD)patients.Methods This was a prospective study.From January 2019 to January 2020,a total of 68 patients with COPD were selected in Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital and Lian Yang Community Health Service Center.These patients were followed up at the scheduled time point.The results of FEV_(1)%pred,SGRQ questionnaire,mMRC score and CAT score were recorded.The patients were divided into group A(mild group)with 49 cases and group B(severe group)with 19 cases.This study analyzed the effects of time changes on the three scoring systems and FEV_(1)%pred.The correlation between the three scoring systems and FEV_(1)%pred was statistically analyzed by Pearson correlation analysis.Results There were no significant difference in FEV_(1)%pred,SGRQ,mMRC and CAT scores with groups·time points(all P>0.05),but there were significant difference between the two groups or time points(all P<0.01),except mMRC(P>0.05).Overall,there were significant differences in FEV_(1)%pred,mMRC and CAT over time(all P<0.05),but there was no significant difference in SGRQ over time(P>0.05).There was no significant difference between the follow-up data of FEV_(1)%pred,SGRQ,mMRC,CAT with the data of enrollment time(all P>0.05),except FEV_(1)%pred 10th and 13th,CAT 7th month.SGRQ was negatively correlated with FEV_(1)%pred at all time points(all P<0.01).FEV_(1)%pred was negatively correlated with mMRC and CAT at 1st and 13th month(all P<0.05),and FEV_(1)%pred was negatively correlated with CAT at 4th,7th and 13th month(all P<0.05).Conclusions CAT score and SGRQ score could reflect the changes of lung function levels of patients.In actual clinical work,the applicability of CAT score should be more applicable than SGRQ s

关 键 词：肺疾病 慢性阻塞性 第1秒用力呼气容积/用力肺活量 圣乔治呼吸问卷 改良版英国医学研究委员会呼吸困难量表 慢性阻塞性肺疾病评估测试 

分 类 号：R563.9[医药卫生—呼吸系统]