血凝素蛋白稳定性对流感病毒生物学特性影响的研究进展  

Influence of the Stability of Avian Influenza Virus Hemagglutinin Protein on Its Biological Characteristics

作　　者：韩雯雯 蔡淼 刘秀梵[1,2] 王晓泉 HAN Wenwen;CAI Miao;LIU Xiufan;WANG Xiaoquan(Animal Infectious Disease Laboratory,College of Veterinary Medicine,Yangzhou Uiversity,Yangzhou,Jiangsu 225009;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis,Yangzhou,Jiangsu 225009)

机构地区：[1]扬州大学兽医学院动物传染病实验室,江苏扬州225009 [2]江苏高校动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009

出　　处：《中国家禽》2021年第8期83-87,共5页China Poultry

基　　金：国家自然科学基金面上项目(31772755)。

摘　　要：流感病毒(Influenza A virus,IAV)可引起人、禽、猪、马、蝙蝠等多种动物感染和发病,是人流感、禽流感、猪流感、马流感等人与动物疫病的病原。当前主要通过疫苗接种的方式控制流感的流行,疫苗的开发研究仍然是防控工作的重点。IAV血凝素(Hemagglutinin,HA)蛋白是疫苗研制的主要靶标,HA蛋白是病毒粒子表面主要糖蛋白之一,介导IAV入侵,也是宿主免疫系统的识别对象。文章就IAV HA蛋白的稳定性影响病毒的复制能力、宿主范围、致病性和气溶胶传播能力等生物学特性的相关研究进行综述,探究流感病毒稳定性对疫苗优化的意义。Influenza A virus(IAV)is one of important pathogens of various animals,including humans,poultry,pigs,horses and bats.IAV poses a constant public health threat worldwide.Vaccination is a major weapon to control the prevalence of IAV and vaccine development remains a priority.Hemagglutinin(HA),as the surface immunogenic protein,is the primary target of current influenza vaccines.The stability of HA is significant for HA′s immunogenicity.Therefore,this article reviewed the effects of HA stability on virus biological properties,which could be of great significance for vaccine optimization.

关 键 词：流感病毒 血凝素 稳定性 疫苗 

分 类 号：S855.3[农业科学—临床兽医学]