阿达木单抗联合丙种球蛋白治疗HSV相关性慢性复发性多形红斑一例  

TNF-αantagonist combined with immunoglobulin in the treatment of herpes virus-related chronic relapsing erythema multiforme:a case report

作　　者：王娜[1] 刘红[1] 吴卫志[1] 张朝霞[1] 周桂芝[1] 施仲香[1] 张福仁[1] WANG Na;LIU Hong;WU Weizhi;ZHANG Zhaoxia;ZHOU Guizhi;SHI Zhongxiang;ZHANG Furen(Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venerology,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院(山东省皮肤病医院),山东省皮肤病性病防治研究所,济南250022

出　　处：《中国麻风皮肤病杂志》2022年第1期34-36,共3页China Journal of Leprosy and Skin Diseases

基　　金：山东省重点研发计划软科学项目(编号:2019RKC03002);山东第一医科大学学术提升计划(编号:2019LJ002,2019RC007)。

摘　　要：本文报道种球蛋白联合阿达木单抗治疗单纯疱疹病毒(HSV)相关的复发性多形红斑1例并复习相关文献。患儿,男,9岁。口唇反复糜烂、渗出15个月,全身反复红斑8个月。皮肤科查体:口唇糜烂,背部、四肢散在暗红色斑片,局部周边可见松弛水疱。病理检查符合多形红斑,单纯疱疹病毒I型IgG滴度444.72 RU/mL。诊断为单纯疱疹病毒感染相关多形红斑,给予伐昔洛韦抗病毒治疗的同时,给予阿达木单抗联合人免疫球蛋白治疗,2周后皮损消退,单纯疱疹病毒I型IgG滴度明显下降。We report a case of herpes simplex virus-related chronic relapsing erythema multiforme(EM)treated with adalimumab and immunoglobulin and review the related literature.A 9-year-old boy presented with repeated lip erosions for 15 months,and erythema all over the body for 8 months.Dermatological examination showed lip erosion,scattered dark red patches on back and limbs,with loosing blisters on the local periphery.The featrue of biopsy was consistent with EM,and the herpes simplex virus type I IgG titer was 444.72 RU/mL.The diagnose of erythema multiforme induced by herpes simplex virus was made.The patient was treated with valaciclovir,adalimumab and immunoglobulin,and the lesions subside after treatment for 2 weeks,and herpes simplex virus type I IgG titer was decreased significantly.

关 键 词：多形红斑 单纯疱疹病毒 肿瘤坏死因子拮抗剂 

分 类 号：R758.61[医药卫生—皮肤病学与性病学]