2,6-二氯苯腈的合成新工艺  

A new synthesis process of 2,6-dichlorobenzonitrile

作　　者：吴浩 顾旻旻 于江 柴华强 贺友兰 尹凯 WU Hao;GU MinMin;YU Jiang;CHAI Huaqiang;HE Youlan;YIN Kai(Zhejiang Nanjiao Chemicals Co.,Ltd.,Shaoxing 312369,Zhejiang,China)

机构地区：[1]浙江南郊化学有限公司,浙江绍兴312369

出　　处：《世界农药》2021年第10期22-24,共3页World Pesticide

摘　　要：2,6-二氯苯腈是苯甲酰脲类农药的重要中间体,目前合成2,6-二氯苯腈的生产成本高,工艺条件苛刻。为了降低生产成本和优化工艺条件,研究开发了以2,6-二氯甲苯为原料经甲基氯化成2,6-二氯三氯苄后,在催化条件下和氯化铵反应合成2,6-二氯苯腈的工艺路线。该工艺路线总收率89%,气相色谱检测含量99.5%以上,具有工业应用前景与价值。2,6-dichlorobenzonitrile is an important intermediate of benzoylurea pesticides.At present,the production cost of 2,6-dichlorobenzonitrile is high and the process conditions are harsh.In order to reduce production costs and optimize process conditions,a new synthesis process of 2,6-dichlorobenzonitrile was developed.The 2,6-dichlorbenzenylchlorid was synthesized from 2,6-dichlorotoluene by chlorination.Then 2,6-dichlorbenzenylchlorid reacted with NH4Cl under catalysis to generate 2,6-dichlorobenzonitrile.The total yield was over 89%and purity was over 99.5%by GC.It has the prospect and value of industrialization.

关 键 词：2 6-二氯苯腈 侧链氯化 2 6-二氯三氯苄 

分 类 号：TQ450[化学工程—农药化工] O625.21[理学—有机化学]