生活方式干预对超重/肥胖人群心血管相关危险因素的影响  

Effect of lifestyle interventions on cardiovascular risk factors in overweight/obese individuals

作　　者：刘沉冰 李楠 邱立红[1] 沈超[1] 刘忠[1] Liu Chenbing;Li Nan;Qiu Lihong;Shen Chao;Liu Zhong(Health Management Center,the First Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院健康管理中心,杭州310003

出　　处：《中华健康管理学杂志》2021年第5期437-441,共5页Chinese Journal of Health Management

摘　　要：目的探讨生活方式干预对超重/肥胖人群心血管相关危险因素的影响。方法选取浙江大学医学院附属第一医院健康管理中心2017年12月—2020年12月进行体重管理的148例超重/肥胖者,其中强化管理组和自我管理组各74例。强化管理组进行为期6个月的生活方式干预,自我管理组进行为期6个月的常规营养运动宣教。干预前后分别采集人口学特征、体格检查指标、生化指标,并对干预效果进行评价。结果自我管理组和强化管理组年龄分别为(42.5±7.5)和(40.1±9.6)岁。强化管理组干预后的体重、体质指数、腰臀比、内脏脂肪面积、收缩压、舒张压、尿酸、同型半胱氨酸、三酰甘油、丙氨酸氨基转移酶、γ-谷氨酰转肽酶分别为(75.6±12.7)kg、(26.72±3.04)kg/m^(2)、0.92±0.05、(104.4±28.5)cm^(2)、(124.2±13.7)mmHg(1 mmHg=0.133 kPa)、(77.8±10.1)mmHg、(353.6±84.8)μmol/L、9.11(7.73,10.00)μmol/L、1.23(0.83,1.91)mmol/L、19.5(13.0,29.5)U/L、19.0(13.0,30.5)U/L,均低于干预前的(81.1±12.5)kg、(28.64±2.82)kg/m^(2)、0.95±0.04、(127.2±26.6)cm^(2)、(132.4±14.7)mmHg、(83.2±10.2)mmHg、(387.2±91.2)μmol/L、10.25(8.30,11.70)μmol/L、1.78(1.40,2.37)mmol/L、28.0(18.0,58.0)U/L、36.0(23.0,54.3)U/L(均P<0.05)。强化管理组体重、体脂率、内脏脂肪面积、收缩压、舒张压、总胆固醇、三酰甘油分别为(75.6±12.7)kg、30.0%(26.3%,34.3%)、(104.4±28.5)cm^(2)、(124.2±13.7)mmHg、(77.8±10.1)mmHg、(4.53±0.83)mmol/L、1.23(0.83,1.91)mmol/L,均低于自我管理组的(80.1±9.2)kg、31.7%(28.5%,38.4%)、(119.5±32.6)cm^(2)、(133.5±15.9)mmHg、(82.6±12.2)mmHg、(4.93±0.86)mmol/L、1.78(1.26,2.97)mmol/L,而高密度脂蛋白胆固醇高于自我管理组的[(1.18±0.28)比(1.09±0.24)mmol/L](均P<0.05)。结论强化生活方式干预对于改善超重/肥胖人群的心血管危险因素有一定效果。Objective To evaluate the effect of lifestyle interventions on cardiovascular risk factors in overweight/obese individuals.Methods A total of 148 overweight/obese subjects who had annual physical exam in the Health Management Center,the First Affiliated Hospital Zhejiang University School of Medicine from Dec 2017 to Dec 2020 were included.They were divided into the self-management group(n=74)and the intervention group(n=74).The intervention group was given a 6-month lifestyle intervention,while the self-management group received regular nutrition and physical activity education.Anthropometric and laboratory data was collected at baseline and after intervention in both groups.Effect of the intervention was evaluated.Results The age of subjects in the intervention and self-management group was(42.5±7.5)and(40.1±9.6)years,respectively.After the intervention,weight,body mass index,waist/hip ratio,visceral fat area,systolic blood pressure,diastolic blood pressure,uric acid,homocystein,triglyceride,alanine aminotransferase andγ-glutamyl transferase of the intervention group[(75.6±12.7)kg,(26.72±3.04)kg/m^(2),0.92±0.05,(104.4±28.5)cm^(2),(124.2±13.7)mmHg(1 mmHg=0.133 kPa),(77.8±10.1)mmHg,(353.6±84.8)μmol/L,9.11(7.73,10.00)μmol/L,1.23(0.83,1.91)mmol/L,19.5(13.0,29.5)U/L,19.0(13.0,30.5)U/L,respectively]were significantly lower than that of the baseline data[(81.1±12.5)kg,(28.64±2.82)kg/m^(2),0.95±0.04,(127.2±26.6)cm^(2),(132.4±14.7)mmHg,(83.2±10.2)mmHg,(387.2±91.2)μmol/L,10.25(8.30,11.70)μmol/L,1.78(1.40,2.37)mmol/L,28.0(18.0,58.0)U/L,36.0(23.0,54.3)U/L,respectively](all P<0.05);compared with the self-management group[(80.1±9.2)kg,31.7%(28.5%,38.4%),(119.5±32.6)cm^(2),(133.5±15.9)mmHg,(82.6±12.2)mmHg,(4.93±0.86)mmol/L,1.78(1.26,2.97)mmol/L,respectively],the intervention group had decreased weight,body fat percent,visceral fat area,systolic blood pressure,diastolic blood pressure,total cholesterol,triglyceride[(75.6±12.7)kg,30.0%(26.3%,34.3%),(104.4±28.5)cm^(2),(124.2±13.7)mmHg,(77.8±10.1)mmH

关 键 词：超重 肥胖症 生活方式 心血管系统 危险因素 

分 类 号：R589.2[医药卫生—内分泌]