血尿酸与心血管健康指数的关联分析临床研究  

The correlation between serum uric acid level and cardiovascular health index: a cross-sectional study

作　　者：毕一鸣 蒋敏 王盛书 徐文焕 曹瑞华[3] 王亚斌[3] 高姗 田磊[2] 郑延松[4] 曾强[4] 范利[5] 曹丰[5] BI Yi-ming;JIANG Min;WANG Sheng-shu;XU Wen-huan;CAO Rui-hua;WANG Ya-bin;GAO Shan;TIAN Lei;ZHENG Yan-song;ZENG Qiang;FAN Li;CAO Feng(Chinese PLA Medical School;Institute of Geriatrics,Second Medical Center,Chinese PLA General Hospital;Department of Cardiology,Second Medical Center,Chinese PLA General Hospital;Health Management Research Institute,Chinese PLA General Hospital;National Clinical Medical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军医学院,北京市100853 [2]解放军总医院第二医学中心老年医学研究所 [3]解放军总医院第二医学中心心血管内科 [4]解放军总医院健康管理研究院 [5]解放军总医院国家老年疾病临床医学研究中心

出　　处：《中国心血管病研究》2021年第10期898-904,共7页Chinese Journal of Cardiovascular Research

基　　金：国家自然科学基金重大研究计划集成项目(91939303);卫健委保健重点课题(2020ZD05)。

摘　　要：目的探讨分析血尿酸水平与查体人群心血管健康指数的相关性。方法纳入2016年至2019年就诊于解放军总医院健康管理研究院的健康查体人群26273名,其中男性16935名,女性9338名。采集所有研究对象的人口学资料、一般临床资料、体格检查数据和生化检查指标,并基于血尿酸水平将总体人群分为不同亚组,采用倾向评分匹配排除混杂因素干扰,进一步分析不同亚组人群的心血管健康水平。结果本研究中,正常尿酸人群中具有理想血压、空腹血糖、总胆固醇、体重指数和膳食情况的人数所占百分比高于高尿酸血症人群,其中达到理想血压、空腹血糖、总胆固醇、体重指数和膳食情况水平的正常尿酸人群分别占总体正常尿酸人群的31.6%、57.1%、65.7%、36.4%和25.3%,而在高尿酸血症人群中仅为17.7%、47.4%、58.6%、18.0%和23.1%,但是两组人群在吸烟和运动情况方面的差异无统计学意义。结论在总体人群中,高尿酸人群的理想心血管健康达标率较正常人群低,提示血尿酸与心血管健康之间存在显著关联。Objective To explore the correlation between serum uric acid level and cardiovascular health index. Methods A total of 26273 physical examination subjects from 2016 to 2019 in the Health Management Institute of PLA General Hospital were recruited, including 16935 males and 9338 females. The clinical data,physical examination data and biochemical examination indexes of all the subjects were recorded to analyze the ideal cardiovascular health level of the general population and the subgroup people based on serum uric acid level.The propensity score matching was used to eliminate the interference of confounding factors, so as to further analyze the cardiovascular health of different subgroups. Results In this study, the normouricemic population had higher percentages of ideal blood pressure, fasting plasma glucose, total cholesterol, body mass index, and dietary situations than the hyperuricemic population, in which normouricemic individuals who achieved ideal blood pressure, fasting plasma glucose, total cholesterol, body mass index, and dietary situations levels had 31.6%,57.1%, 65.7%, 36.4%, and 25.3%, respectively, of the overall normouricemic population, However, it was only 17.7%, 47.4%, 58.6%, 18.0% and 23.1% in hyperuricemia population, but the two groups did not show significant statistical difference in terms of smoking and exercise. Conclusion This study indicates that the level of blood uric acid is negatively correlated with cardiovascular health index.

关 键 词：血尿酸 理想心血管健康指数 心血管健康 横断面研究 

分 类 号：R589.7[医药卫生—内分泌]