缺血伴非阻塞性冠状动脉疾病的研究现状  

Research status of Ischemia with non obstructive coronary artery disease

作　　者：周磊 张庆全 鄢华[1] 朱汉东[1] ZHOU Lei;ZHANG Qing-quan;YAN Hua;ZHU Han-dong(Department of Cardiology,Wuhan Asian heart hospital,Wuhan 430022,China)

机构地区：[1]武汉亚洲心脏病医院心内科,湖北省武汉市430022

出　　处：《中国心血管病研究》2021年第10期940-944,共5页Chinese Journal of Cardiovascular Research

摘　　要：缺血性心脏病是世界范围内主要的疾病负担之一,其诊疗策略的制定主要是依据冠状动脉的影像学信息。然而,在临床实践中,冠状动脉造影和腔内影像技术提供的信息并不能很好地解释心肌缺血。缺血伴非阻塞性冠状动脉疾病(NOICAD)是指患者存在心肌缺血症状和(或)证据,但冠状动脉造影无明显的血管狭窄(即狭窄<50%)的疾病。其在临床上普遍存在并且是导致患者反复住院、生活质量降低和发生不良心血管事件的主要原因之一。目前,NOICAD的病因发病机制尚未明确,诊断和治疗手段有限。因此,本文从NOICAD发病机制、诊断、治疗等方面的最新研究进展予以总结阐述。Ischemic heart disease is one of the major health burden in the world, and its diagnosis and treatment strategy is mainly rely on the imaging information of coronary artery. However, in the clinical practice,the information provided by coronary angiography and endovascular imaging technology can’t well explain the myocardial ischemia. Non obstructive ischemic coronary artery disease(NOICAD) refers to patients with obvious myocardial ischemia, but coronary angiography shows that the coronary artery is normal or close to normal(stenosis <50%). It is common in clinical practice and one of the main causes of repeated hospitalization,decreased quality of life and adverse cardiovascular events. At present, the etiology and pathogenesis of NOICAD are still not clear the diagnosis and therapy also limited. Therefore, this article summarizes the latest research progress in the pathogenesis, diagnosis and treatment of NOICAD.

关 键 词：冠状动脉微循环障碍 非阻塞性冠状动脉疾病 冠状动脉痉挛 

分 类 号：R541.4[医药卫生—心血管疾病]