微通道连续均相催化Knoevenagel缩合反应实验研究  

Experimental study on continuous and homogeneous catalytic Knoevenagel condensation reaction in microchannel reactor

作　　者：陈秋实 任玉婧 郑辰 张敏弟[1] 黎汉生 史大昕 CHEN Qiu-shi;REN Yu-jing;ZHENG Chen;ZHANG Min-di;LI Han-sheng;SHI Da-xin(School of Mechanical Engineering,Beijing Institute of Technology,Beijing 100081,China;School of Chemistry and Chemical Engineering,Beijing Institute of Technology,Beijing 100081,China)

机构地区：[1]北京理工大学机械与车辆学院,北京100081 [2]北京理工大学化学与化工学院,北京100081

出　　处：《现代化工》2021年第10期68-72,77,共6页Modern Chemical Industry

基　　金：国家自然科学基金(21576025,51979003)。

摘　　要：利用微通道反应器进行苯甲醛和氰乙酸乙酯的均相催化Knoevenagel缩合反应,以出口位置苯甲醛转化率为指标,考察反应温度、反应物浓度、反应物摩尔比、停留时间、催化剂摩尔分数和微通道几何尺寸对实验结果的影响。结果表明,微通道管径越小,反应物转化率越高;增加微通道管长或降低物料进口流速都会延长反应物的停留时间,当温度为335.15 K、停留时间为30 min时,反应器出口位置的转化率可达80.4%;保持停留时间不变,温度每提高10 K,转化率平均提高约10.8%。基于该实验结果进行Design of Experiment(DOE)试验设计,分析了各种条件对实验结果的影响,并建立了以转化率为指标的估算预测模型。微通道反应器能够在保证较高转化率的同时实现连续生产,具有良好的应用前景。The homogeneous catalytic Knoevenagel condensation reaction between benzaldehyde and ethyl cyanoacetate is proceeded in a microchannel reactor.Taking the conversion of benzaldehyde at the outlet as the index,the effects of temperature,reactants concentration,proportion between reactants,residence time,catalyst dosage,and microchannel geometry on the experimental results are investigated. Experimental result shows that a smaller diameter leads to a higher conversion of benzaldehyde significantly. Both a longer microchannel pipe and a lower flow rate of materials at the inlet will prolong the residence time of reactants.The conversion at the outlet reaches 80. 4% when the temperature is at 335. 15 K and the residence time is 30 min. For every 10 K increase in temperature,the conversion increases by 10. 8% averagely with the same residence time.Design Of Experiment( DOE) is based on the experimental results,which quantitatively investigates the influence of the conditions and then establishes a prediction model with the conversion as index. It is verified that microchannel reactor can achieve continuous production while ensuring a high conversion,and represents a good application prospect.

关 键 词：微通道反应器 KNOEVENAGEL反应 DOE 苯甲醛 氰乙酸乙酯 

分 类 号：TQ2[化学工程—有机化工]