深圳口岸出入境人员与当地人群HIV-1 CRF08_BC流行株基因相关性研究  

Study of relationship on circulating HIV-1 CRF08_BC strain among enter-exit personnel and local population in Shenzhen

作　　者：刘胜牙 陈震[3] 徐媛 冯毅[4] 陈琳[5] 李微 赵倩 陈琛 LIU Sheng-ya;CHEN Zhen;XU Yuan;FENG Yi;CHEN Lin;LI Wei;ZHAO Qian;CHEN Chen(Shenzhen International Travel Health Care Center(Shenzhen Customs Port Clinic),Shenzhen,Guangdong 518033 China;不详)

机构地区：[1]深圳国际旅行卫生保健中心(深圳海关口岸门诊部),广东深圳518033 [2]深圳市检验检疫科学研究院 [3]深圳市宝安区疾病预防控制中心 [4]中国疾病预防控制中心性病艾滋病预防控制所 [5]深圳市疾病预防控制中心

出　　处：《中国国境卫生检疫杂志》2021年第5期305-308,共4页Chinese Journal of Frontier Health and Quarantine

基　　金：国家自然科学基金项目(81102174);深圳市实施标准化战略资金资助项目(2015BZYZHY0102)。

摘　　要：目的分析深圳口岸出入境人员与当地人群中流行的HIV-1 CRF08BC毒株的基因相关性,为制定相应的防控策略提供依据。方法以深圳口岸出入境人员与当地人群中HIV-1感染者为研究对象,获得两个人群的HIV-1基因序列并判定基因型,分别用传播网络和系统进化分析方法研究两个人群中HIV-1 CRF08BC流行株的关联情况。结果 HIV-1 CRF08BC流行株传播网络模式图显示,两个人群中流行的毒株基因序列之间无关联。近似最大似然法系统进化树显示,两个人群中的其他毒株基因序列均呈散在分布。结论深圳口岸出入境人员与当地人群中流行的HIV-1 CRF08BC毒株之间无明显相关性。Objective To analyze the gentic correlation of HIV-1 CRF08_BC strains between entry-exit personnel at Shenzhen port and local population,so as to lay the foundation for the prevention and control policies formulation. Methods The HIV-1 gene sequences were obtained from the entry-exit personnel and local people in Shenzhen,and the genotypes were determined. The transmission network and phylogenetic analysis were used to study the association of HIV-1 CRF08_BC strains in the two populations. Results The network pattern of HIV-1 CRF08_BC subtype showed that there was no correlation between the gene sequences of prevalent strains from these two populations. The phylogenetic tree of approximate maximum likelihood method on HIV-1 CRF08_BC subtype showed that the viral gene sequences from these two populations was scattered. Conclusion There is no association on circulating HIV-1 CRF08_BC strains among the entry-exit personnel at Shenzhen port and the local population.

关 键 词：出入境人员 艾滋病病毒 基因 基因相关性 

分 类 号：R183[医药卫生—流行病学]