乳腺癌超声造影征象与高尔基磷酸化蛋白3表达的关系  

Relationship between contrast-enhanced ultrasonography and GOLPH3 protein expression in breast cancer

作　　者：塔娜[1] 王霞[1] 李文娟 张爱红 TA NA;WANG Xia;LI Wenjuan(Department of Diagnostic Ultrasound,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830063,China)

机构地区：[1]新疆医科大学第二附属医院超声诊断科,830063 [2]广东省东莞市康华医院超声科

出　　处：《临床外科杂志》2021年第9期838-842,共5页Journal of Clinical Surgery

基　　金：新疆维吾尔自治区自然科学基金资助项目(2019D01C241)。

摘　　要：目的分析乳腺癌超声造影征象与高尔基磷酸化蛋白3(golgi phosphoprotein 3,GOLPH3)表达的关系。方法回顾性分析107例经病理检查证实的乳腺癌病人的超声造影征象,免疫组织化学法检测乳腺癌组织中GOLPH3的表达,分析GOLPH3阳性与阴性乳腺癌与始增时间、达峰时间、峰值加速时间、始增速度及增强速率及预后的关系。结果GOLPH3不同表达强度病人间年龄、肿瘤大小比较差异无统计学意义(P=0.431,0.238),淋巴结转移、临床分期差异有统计学意义(P<0.05)。乳腺癌组织中GOLPH3表达阳性率为81.21%(87/107)。乳腺癌超声造影的特征以不均匀部分增强及整体性增强为主,时间-强度曲线呈"快进慢出"或"快进快出"型。GOLPH3阳性乳腺癌的始增时间、达峰时间、峰值加速时间小于GOLPH3阴性乳腺癌,GOLPH3阳性乳腺癌始增速度、增强速率大于GOLPH3阴性乳腺癌,差异有统计学意义(P<0.05)。不同GOLPH3表达水平及超声造影参数乳腺癌病人的5年生存率比较,差异有统计学意义(P<0.05)。结论乳腺癌的超声造影参数与GOLPH3的表达相关。Objective To analyze the relationship between contrast-enhanced ultrasound(CEUS)parameters and the expression of golgi phosphoprotein 3(GOLPH3)in breast cancer.Methods A total of 107 breast cancer patients confirmed by pathology were recruited,and the characteristic of CEUS were analyzed.The expression of GOLPH3 was detected by immunohistochemistry.The relationship betweenGOLPH3 positive and negative breast cancer and initial increasing time,peak acceleration time,initial increasing rate and enhancement rate was analyzed.Results There were no significant differences in age and tumor size among patients with different expression levels of golph3(P=0.431,0.238),but there were significant differences in lymph node metastasis and clinical stage(P=0.011,0.005).The positive rate of VEGF expression was 81.21%(87/107).The characteristics of breast cancer contrast-enhanced ultrasound were mainly uneven partial enhancement and overall enhancement.The time-intensity curve was"fast in and out"or"fast in and out"type.The initial increase time,peak time and peak acceleration time of GOLPH3 positive breast cancer were lower than those of GOLPH3 negative breast cancer,and the enhancement rate of GOLPH3 positive breast cancer was higher than that of GOLPH3 negative breast cancer,the difference was statistically significant(P<0.05).The 5-year survival rates of breast cancer patients with different golph3 expression levels and CEUS parameters were statistically significant(P<0.05).Conclusion The contrast-enhanced ultrasound parameters of breast cancer are closely related to the expression of GOLPH3,which may be valuable to diagnose breast cancer.

关 键 词：乳腺癌 超声造影 GOLPH3 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]