肝肾亏虚型退行性腰椎椎管狭窄症相关基因多态性的研究进展  

Research Progress of Related Gene Polymorphisms in Degenerative Lumbar Spinal Stenosis of Liver and Kidney Deficiency Pattern

作　　者：罗林钊 邓强[2] 张彦军[2] 郭铁峰[2] 杜凯然 魏美娟 刘晓雪 李家明 LUO Linzhao;DENG Qiang;ZHANG Yanjun;GUO Tiefeng;DU Kairan;WEI Meijuan;LIU Xiaoxue;LI Jiaming(Gansu University of Traditional Chinese Medicine,Lanzhou 730030,China;Gansu Provincial Hospital of Traditional Chinese Medicine;Qinghai University)

机构地区：[1]甘肃中医药大学,甘肃兰州730030 [2]甘肃省中医院 [3]青海大学

出　　处：《西部中医药》2021年第9期147-150,共4页Western Journal of Traditional Chinese Medicine

基　　金：甘肃省卫生行业科研计划项目(GSWSKY2016-01)。

摘　　要：从退行性腰椎椎管狭窄症(degenerative lumbar spinal stenosis,DLSS)相关中医证型的发病机制研究及DLSS与基因多态性的相关性研究入手探讨肝肾亏虚型DLSS的相关基因多态性,指出基于椎间盘退变机制的营养、生物力学、遗传学及分子生物学等致病原因,其中与其可能存在紧密关系的基因有HOX基因家族、胶原蛋白基因家族、上皮细胞膜蛋白(EMP-1)基因、Sox9基因、Pax1基因、TGF-β等,而肝肾亏虚型DLSS症状表现与其基因多态性可能存在关联性,可根据中医辨证论治理论,结合现代基因组学研究方法,进一步探讨肝肾亏虚型DLSS患者椎间盘、骨骼细胞、蛋白等变化,为DLSS早期辨体、辨证及施治提供科学依据。The paper discusses the related gene polymorphism of degenerative lumbar spinal stenosis(DLSS)of liver and kidney deficiency pattern from the study on the pathogenesis of the related TCM patterns of DLSS and the correlation study between DLSS and gene polymorphism,it points out that,among them,the genes might be closely related to pathogenic causes of DLSS including nutrition,biomechanics,genetics and molecular biology of the mechanism of intervertebral disc degeneration,containing HOX gene family,collagen gene family,epithelial membrane protein(EMP-1)gene,Sox9 gene,Pax1 gene,TGFβand others,while the symptoms and manifestations of DLSS of liver and kidney deficiency pattern may be associated with its gene polymorphism,according to TCM theory of syndrome differentiation and treatment,combined with modern genomics research methods,we can further study and explore the changes of intervertebral disc,skeletal cells and protein in patients with DLSS of liver and kidney deficiency pattern,so as to provide scientific basis for early identification,syndrome differentiation and treatment of DLSS.

关 键 词：腰椎椎管狭窄症 基因多态性 肝肾亏虚 综述 

分 类 号：R681[医药卫生—骨科学]