糖尿病肾病患者血清白脂素水平与肾功能和糖代谢指标的相关性研究  

Correlation study of serum asprosin levels with renal function and glucose metabolism indexes in patients with diabetic nephropathy

作　　者：吴勇[1] 林伟平 李斯毅[1] 杨立文 刘滢[1] Wu Yong;Lin Weiping;Li Siyi;Yang Liwen;Liu Ying(Department of Nephrology,Huizhou Central People's Hospital,Huizhou 516000,China)

机构地区：[1]惠州市中心人民医院肾内科,惠州516000

出　　处：《中华肥胖与代谢病电子杂志》2021年第2期104-107,共4页Chinese Journal Of Obesity and Metabolic Diseases：Electronic Edition

摘　　要：目的探讨糖尿病肾病(DKD)患者血清白脂素(asprosin)水平与肾功能和糖代谢指标及临床意义。方法选取2020年1月至2021年2月于惠州市中心人民医院就诊的2型糖尿病(T2DM)患者共84例,诊断为T2DM的患者共43例(T2DM组),诊断为T2DM合并DKD的共41例(T2DM并DKD组),健康体检的对照参与者40例作为对照组。收集所有参与者的体质量指数(BMI)、2型糖尿病病程、患者的收缩压(SBP)和舒张压(DBP)、肌酐(Cr)、尿素氮(BUN)、空腹血糖(FPG)、糖化血红蛋白(HbAlc)、空腹血清胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR),采用ELISA检测血清asprosin水平,并分析asprosin与相关指标的关系。结果T2DM组的血清asprosin、Cr、FPG、HbAlc、FINS和HOMA-IR水平显著高于对照组,T2DM并DKD组的血清asprosin、Cr、FPG、HbAlc、FINS和HOMA-IR水平显著高于T2DM组和对照组(P<0.01);血清asprosin水平与Cr、FPG、HbAlc、FINS的水平呈显著的正相关(P<0.01),与年龄、BMI、SBP、DBP和BUN的水平没有显著的相关性(P>0.05)。结论T2DM合并DKD患者的血清asprosin水平显著升高,且与肾功指标和糖代谢指标正相关。Objective To investigate the level of serum asprosin,renal function and glucose metabolism indexes and clinical significance in patients with diabetic nephropathy(DKD).Methods A total of 84 patients with type 2 diabetes(T2 DM)who were treated in Huizhou Central People’s Hospital from January 2020 to February 2021 were selected,a total of 43 patients were diagnosed with T2 DM(T2 DM group),and a total of 41 patients were diagnosed with T2 DM combined with DKD(T2 DM and DKD group).Forty control participants served as a control group.All participants’body mass index(BMI),course of type 2 diabetes,patient’s systolic blood pressure(SBP)and diastolic blood pressure(DBP),creatinine(Cr),urea nitrogen(BUN),fasting blood glucose(FPG),glycosylated hemoglobin(HbAlc),Fasting Serum Insulin(FINS),Insulin Resistance Index(HOMA-IR)were collected,and serum asprosin levels were detected by ELISA.The relationship between asprosin and related indicators was analyzed.Results The serum asprosin,Cr,FPG,HbAlc,FINS and HOMA-IR levels in the T2 DM group were significantly higher than those in the control group.The serum asprosin,Cr,FPG,HbAlc,FINS and HOMA-IR levels in the T2 DM and DKD group were significantly higher than those in T2 DM Group and control group(P<0.01);serum asprosin levels are significantly positively correlated with Cr,FPG,HbAlc,and FINS levels(P<0.01),and there is no significant correlation with age,BMI,SBP,DBP and BUN levels Sex(P>0.05).Conclusions Serum asprosin levels in patients with T2 DM combined with DKD are significantly increased,and are positively correlated with renal function indexes and glucose metabolism indexes.

关 键 词：Asprosin 糖尿病肾病 2型糖尿病 肌酐 胰岛素抵抗 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]