Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury  

作　　者：Yi-Xin Wang Jin-Zhu Bai Zhen Lyu Guang-Hao Zhang Xiao-Lin Huo 

机构地区：[1]Department of Spine and Spinal Cord Surgery,Beijing Bo’ai Hospital,Rehabilitation Research Center,Beijing,China [2]School of Rehabilitation Medicine,Capital Medical University,Beijing,China [3]Beijing Key Laboratory of Bioelectromagnetism,Institute of Electrical Engineering,Chinese Academy of Sciences,Beijing,China [4]School of Electronics,Electrical and Communication Engineering,University of Chinese Academy of Sciences,Beijing,China

出　　处：《Neural Regeneration Research》2022年第6期1318-1323,共6页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China,No.30801222(to JZB).

摘　　要：Oscillating field stimulation(OFS)is a potential method for treating spinal cord injury.Although it has been used in spinal cord injury(SCI)therapy in basic and clinical studies,its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood.In this study,we established rat models of spinal cord contusion at T10 and then administered 12 weeks of OFS.The results revealed that effectively promotes the recovery of motor function required continuous OFS for more than 6 weeks.The underlying mechanism may be related to the effects of OFS on promoting axon regeneration,inhibiting astrocyte proliferation,and improving the linear arrangement of astrocytes.This study was approved by the Animal Experiments and Experimental Animal Welfare Committee of Capital Medical University(supplemental approval No.AEEI-2021-204)on July 26,2021.

关 键 词：astrocyte orientation astrocyte proliferation axonal regeneration locomotor recovery neural regeneration neural repair oscillating field stimulation spinal cord injury stimulus duration 

分 类 号：R454.1[医药卫生—治疗学] R744[医药卫生—临床医学]