双曲线传热模型在微波消融治疗房颤中的应用研究  

Application of hyperbolic heat transfer model in atrial fibrillation microwave ablation

作　　者：张萌[1,2] 田甄 程妍妍[1,2] 刘洪兴 南群 ZHANG Meng;TIAN Zhen;CHENG Yanyan;LIU Hongxing;NAN Qun(Department of Biomedical Engineering,Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,P.R.China;Intelligent Physiological Measurement and Clinical Translation,Beijing International Base for Scientific and Technological Cooperation,Beijing 100124,P.R.China)

机构地区：[1]北京工业大学环境与生命学部生物医学工程系,北京100124 [2]智能化生理测量与临床转化北京市国际科研合作基地,北京100124

出　　处：《生物医学工程学杂志》2021年第5期885-892,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金(31771021,11832003);北京市自然科学基金(3162006);江苏省科技基金(BE2017758)。

摘　　要：探究双曲线传热模型中弛豫时间对房颤微波消融温度场的影响,并与采用Pennes模型计算得到的心肌组织温度场进行比较。构建了房颤微波消融的三维模型,弛豫时间(τ)取0、1、5、8、10、15、20 s,得到心肌组织的温度场,结果表明,消融开始时,双曲线模型的心肌组织最高温度低于Pennes模型的心肌组织最高温度,最大相差21.8℃。随着消融时间增大,最高温度逐渐趋于一致。且不同的弛豫时间分别在消融时间达到3、4、6、7、8、9、10 s时才开始出现损伤区域。因此双曲线模型对温度的影响会随着消融时间的增大而减小,且在消融开始时弛豫时间会阻碍心肌热扩散的速度,弛豫时间越大,热扩散的速度越慢,为双曲线模型在房颤微波消融中的应用提供参考。The effect of relaxation time in hyperbolic heat transfer model on the temperature field of microwave ablation of atrial fibrillation was investigated. And the results were compared with those calculated by Pennes model. A three-dimensional model of microwave ablation of atrial fibrillation was constructed. The relaxation time(τ) was 0, 1, 5, 8,10, 15 and 20 s, respectively. And the temperature field of myocardial tissue was obtained. The results showed that the highest temperature of the hyperbolic model was 21.8 ℃ lower than that of the Pennes model at the beginning of ablation.With the increase of ablation time, the highest temperature tended to be the same. The lesion dimensions appeared at 3, 4,6, 7, 8, 9, and 10 s, respectively after ablation. Therefore, the influence of hyperbolic model on temperature will decrease with the increase of the ablation time. At the beginning of ablation, the relaxation time will hinder the speed of myocardial thermal diffusion. The larger the relaxation time is, the slower the speed of thermal diffusion is. This study provides a reference for the application of hyperbolic model in microwave ablation of atrial fibrillation.

关 键 词：房颤 双曲线模型 Pennes模型 弛豫时间 温度分布 

分 类 号：R541.75[医药卫生—心血管疾病]