甲状旁腺素及甲状旁腺素相关肽在骨组织工程中的原位应用  

Local administration of parathyroid hormone and parathyroid hormone-related peptides for bone tissue engineering

作　　者：郝卓文(综述) 李景峰(审校)[1] HAO Zhuowen;LI Jingfeng(Department of Spine Surgery and Musculoskeletal Tumor,Zhongnan Hospital,Wuhan University,Wuhan 430071,P.R.China)

机构地区：[1]武汉大学中南医院脊柱与骨肿瘤科,武汉430071

出　　处：《生物医学工程学杂志》2021年第5期1028-1034,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(81871752);湖北省自然科学基金资助项目(2020CFB551);武汉大学中南医院国家自然科学基金培育项目(znpy2019074)。

摘　　要：甲状旁腺素(PTH)具有调节骨重构、促血管生成等多重作用,是一种极具应用潜力的骨修复活性因子。近年来,随着支架材料负载策略、甲状旁腺素相关肽(PTHrPs)的发展,支架材料原位负载PTH或PTHrPs治疗促进骨缺损愈合逐渐成为可能。本文基于系统间歇性PTH(iPTH)应用于骨组织工程的现状与挑战,就PTH的原位负载策略及PTHrPs的构建两方面进行阐述,并探讨了该领域存在的问题及未来的研究方向,以期促进支架材料原位负载PTH或PTHrPs的临床应用。Parathyroid hormone(PTH)exerts multiple effects such as regulating bone remodeling,promoting angiogenesis,etc.,and it is an active factor with great application potential for bone repair.In recent years,with the development of scaffold material loading strategies and parathyroid hormone-related peptides(PTHrPs),in situ loading of PTH or PTHrPs on scaffold materials to promote bone defect healing gradually becomes possible.Based on the current status and challenges of intermittent PTH(iPTH)for bone tissue engineering,the review summarizes the in-situ application strategies of PTH and the construction of PTHrPs as well as current problems and further directions in this field,with a view to propel the clinical application of scaffold materials loaded with PTH or PTHrPs in situ.

关 键 词：甲状旁腺素 甲状旁腺素相关肽 骨愈合 骨再生 原位负载策略 

分 类 号：R69[医药卫生—泌尿科学]