消旋山莨菪碱穴位注射干预糖尿病周围神经病变疗效观察  

Observation on the curative effect of acupoint injection of racemic anisodamine in intervention of diabetic peripheral neuropathy

作　　者：刘颖 郑晓军[1] 纪春敏[1] 洪冠宇[1] 何志忠[1] LIU Ying;ZHENG Xiaojun;JI Chunmin;HONG Guanyu;HE Zhizhong(Quanzhou Hospital of Traditional Chinese Medicine, Quanzhou 362000, Fujian, China)

机构地区：[1]泉州市中医院,福建泉州362000

出　　处：《现代中西医结合杂志》2021年第30期3349-3353,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：泉州市科技计划项目(201811151208861)。

摘　　要：目的观察消旋山莨菪碱注射液穴位注射干预糖尿病周围神经病变的临床疗效及安全性。方法将2018年9月—2020年12月泉州市中医院收治的110例糖尿病周围神经病变患者随机分成治疗组和对照组各55例,对照组给予降糖等基础治疗联合依帕司他、硫辛酸注射液治疗,治疗组在对照组治疗的基础上给予消旋山莨菪碱双侧足三里穴位注射,共治疗2周,观察2组治疗前后临床症状积分、多伦多临床评分(TCSS)、腓总神经和胫神经运动传导速度及临床疗效、不良反应。结果2组治疗后临床症状积分、TCSS均较治疗前明显下降(P均<0.05),腓总神经和胫神经运动传导速度均较治疗前明显加快(P均<0.05)。治疗后治疗组临床症状积分、TCSS均明显低于对照组(P均<0.05),但2组治疗后双侧腓总神经和双侧胫神经运动传导速度比较差异均无统计学意义(P均>0.05)。治疗组治疗后总有效率为81.8%(45/55),显著高于对照组的67.3%(37/55),差异有统计学意义(P<0.05)。治疗组出现口干症状5例,排尿不畅4例,不良反应发生率为16.3%,对照组未见明显不良反应。治疗前后2组肝肾功能无明显变化。结论消旋山莨菪碱穴位注射干预糖尿病性周围神经病变可有效改善临床症状,不良反应较少,操作简便。Objective It is to observe the clinical efficacy and safety of acupoint injection of racemic anisodamine injection in intervention of diabetic peripheral neuropathy.Methods A total of 110 patients with diabetic peripheral neuropathy admitted to Quanzhou Hospital of Traditional Chinese Medicine from September 2018 to December 2020 were randomly divided into a treatment group and a control group,each group had 55 cases.The control group was given basic therapies such as hypoglycemia combined with epalrestat and lipoic acid injection,the treatment group was given acupoint injections of racemic anisodamine at bilateral Zusanli points on the basis of the treatment of the control group,both groups were treated for a total of 2 weeks.The clinical symptom score,Toronto clinical scoring system(TCSS)score,common peroneal nerve and tibial nerve motor conduction velocity were observed before and after treatment in the two groups,the clinical efficacy was assessed and occurrence of adverse reactions was recorded.Results The clinical symptom scores and TCSS scores after treatment were significantly lower than those before treatment,and the motor conduction velocity of the common peroneal nerve and tibial nerve were significantly faster than those before treatment in the two groups(all P<0.05).After treatment,the clinical symptom score and TCSS scores of the treatment group were significantly lower than those of the control group(all P<0.05),but there was no significant difference in the motor conduction velocity of the bilateral common peroneal nerve and bilateral tibial nerve between the two groups(all P>0.05).The total effective rate after treatment in the treatment group was 81.8%(45/55),which was significantly higher than 67.3%(37/55)in the control group,and the difference was statistically significant(P<0.05).There were 5 cases of dry mouth and 4 cases of poor urination in the treatment group,the adverse reaction rate was 16.3%,there was no obvious adverse reaction in the control group.There was no significant change in l

关 键 词：消旋山莨菪碱注射液 穴位注射 糖尿病周围神经病变 

分 类 号：R587.2[医药卫生—内分泌]