薄氏腹针联合HCG对肾虚血瘀型黄素化未破裂卵泡综合征患者血清E2、LH、FSH及排卵率的影响  

Effect of BO’s Abdominal Acupuncture Combined with HCG on Serum E2,LH,FSH and Ovulation Rate in Patients with LUFS of Kidney-Deficiency and Blood Stasis Pattern

作　　者：张春华 王慧颖 毕艳慧 陈国姿 高新源 ZHANG Chunhua;WANG Huiying;BI Yanhui;CHEN Guozi;GAO Xinyuan(Shenzhen Hospital,Beijing University of Chinese Medicine,Shenzhen 518055,China)

机构地区：[1]北京中医药大学深圳医院,广东深圳518055

出　　处：《针灸临床杂志》2021年第9期21-25,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：广东省中医药局面上科研项目,编号:20191285。

摘　　要：目的:探究薄氏腹针联合人绒毛膜促性腺激素(HCG)对肾虚血瘀型黄素化未破裂卵泡综合征(LUFS)患者血清雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)及排卵率的影响。方法:本研究拟采用随机、对照的研究方法,选取2019年1月—2019年12月期间就诊于北京中医药大学深圳医院妇科门诊90例肾虚血瘀型LUFS患者作为研究对象,采用随机数字表法分为3组,每组各30例,联合治疗组给予薄氏腹针联合HCG治疗,针刺组给予薄氏腹针治疗,HCG组给予HCG治疗。比较3组血清雌二醇(E2)、黄体生成素(LH)、FSH水平和中医证侯积分、卵巢卵泡期血流灌注情况、排卵率及妊娠率的改善情况。结果:治疗后,3组中医证候总积分比较,联合治疗组低于针刺组,针刺组低于HCG组,差异具有统计学意义(P<0.05)。治疗后,3组血清E2、LH、FSH水平、卵巢动脉阻力指数(RI)和搏动指数(PI)比较,联合治疗组高于针刺组和HCG组,针刺组高于HCG组。治疗后,3组最大血流速度(PSV)比较,联合治疗组低于针刺组和HCG组,针刺组低于HCG组,差异具有统计学意义(P<0.05)。治疗后3组排卵率、妊娠率比较,联合治疗组高于针刺组和HCG组,针刺组高于HCG组,差异具有统计学意义(P<0.05)。结论:薄氏腹针联合HCG治疗肾虚血瘀型LUFS患者,可有效促进E2、LH合成,改善机体激素水平,改善中医证候积分和卵巢血流灌注,提高排卵率、妊娠率,值得在临床推广。Objective:To investigate the effect of BO’s abdominal acupuncture combined with human chorionic gonadotropin(HCG)on serum Estradiol(E2),Luteinizing hormone(LH),follicle-stimulating hormone(FSH)and ovulation rate in patients with luteinized unruptured follicle syndrome(LUFS)of Kidney-deficiency and blood stasis pattern.Methods:90 patients with LUFS of Kidney-deficiency and blood stasis pattern were randomly divided into the HCG group,the acupuncture group and the combination group,with 30 patients in each group.The HCG group was treated with HCG,the acupuncture group was treated with BO’s abdominal acupuncture,and the combination group was treated with HCG combined with BO’s abdominal acupuncture.The levels of E2,LH and FSH,as well as the improvements of TCM syndrome integral,the condition of blood perfusion in ovarian follicle,ovulation rate and pregnancy rate were compared among the three groups after the treatment.Results:The TCM syndrome integral of the combination group was the lowest,followed by the acupuncture group and the HCG group(P<0.05).The serum levels of E2,LH and FSH,as well as resistance index(RI)and pulsatility index(PI)of ovarian artery were the highest in the combination group followed by the acupuncture group and the HCG group(P<0.05).The peak systolic velocity(PSV)was lower in the combination group than that in the acupuncture group,also the acupuncture group was lower than the HCG group(P<0.05).The ovulation rate and pregnancy rate were higher in the combination group than those in the acupuncture group,and the acupuncture group was also higher than the HCG group(P<0.05).Conclusion:BO’s abdominal acupuncture combined with HCG can effectively promote the synthesis of E2 and LH,improve the hormone levels,the TCM syndrome integral and ovarian perfusion,and increase the ovulation rate and pregnancy rate,which is worthy of clinical promotion.

关 键 词：黄素化未破裂卵泡综合征 薄氏腹针 人绒毛膜促性腺激素 雌二醇 黄体生成素 排卵率 

分 类 号：R246.3[医药卫生—针灸推拿学]