肌肉减少症:肝移植的新挑战  

Sarcopenia:a new challenge in liver transplantation

作　　者：徐骁[1] 陈昊[1] 鲁迪 林祖源 Xu Xiao;Chen Hao;Lu Di;Lin Zuyuan(Department of Hepatobiliary and Pancreatic Surgery,the Center for Integrated Oncology and Precision Medicine,Affiliated Hangzhou First People′s Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China)

机构地区：[1]浙江大学医学院附属杭州市第一人民医院肝胆胰外科肿瘤融合研究与精准诊治实验室,310006

出　　处：《中华消化外科杂志》2021年第10期1025-1030,共6页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金(81930016);国家杰出青年科学基金(81625003)。

摘　　要：肝移植是终末期肝病病人的首选治疗手段。肌肉减少症是一种以肌肉量减低和肌肉功能减退为特征的骨骼肌疾病。在移植术前肝硬化、肝癌病人中,肌肉减少症是常见但易被忽视的并发症,其直接影响病人肝移植等待期间死亡及转归。针对肌肉减少症进行科学评判、精细化分层有望实现精准干预并改善肝移植受者的预后。在肝移植受者围手术期及中长期管理中,肌肉减少症的重要性日益突显,应纳入规范化临床诊断与治疗体系。笔者回溯国内外研究成果,全面阐述肝移植中肌肉减少症的研究进展,旨在提高我国对肝移植受者肌肉减少症的认知和重视。Liver transplantation remains as the first choice treatment for patients with end stage liver diseases.Sarcopenia is a skeletal muscle disease characterized by loss of muscle mass and muscle function.As a common but easily overlooked complication,sarcopenia significantly influences the death and prognosis of recipients with cirrhosis and liver cancer waiting liver trans-plantation,which significantly influences the death and prognosis of those patients.Scientific evalua-tion and fine stratification of sarcopenia are expected to achieve precision intervention and improve prognosis of liver transplantation recipients.As sarcopenia is increasingly important in perioperative as well as medium and long-term management of liver transplantation recipients,it should be incorporated into normalized clinical diagnosis and treatment system.The authors review the research results at home and abroad,and comprehensively expound the research progress of sarcopenia in liver transplantation,in order to improve the cognition of sarcopenia in liver transplan-tation recipients in China.

关 键 词：终末期肝病 肝移植 肌肉减少症 肝硬化 肝癌 预后 

分 类 号：R685[医药卫生—骨科学]